Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | EBP | Q15125 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10410244 | 0.91 | SIGMAR1 (0.51) | SIGMAR1EBPTMEM97BCHEDRD2 | |
| SCHEMBL11672572 | 0.84 | BCHE (0.43) | BCHEOPRM1OPRD1OPRK1 | |
| SCHEMBL10410171 | 0.83 | SIGMAR1 (0.53) | SIGMAR1EBPTMEM97DRD2OPRM1 | |
| SCHEMBL6812942 | 0.83 | FOLH1 (0.45) | — | |
| Bromide SCHEMBL10553517 | 0.82 | SIGMAR1 (0.52) | SIGMAR1EBPTMEM97DRD2OPRM1 | |
| SCHEMBL5665750 | 0.81 | KDM4E (0.38) | BCHEDRD2OPRM1DRD3OPRD1 | |
| Bromide SCHEMBL10805839 | 0.81 | SIGMAR1 (0.54) | SIGMAR1EBPTMEM97BCHEDRD2 | |
| SCHEMBL10555893 | 0.81 | SIGMAR1 (0.48) | SIGMAR1EBPTMEM97BCHEDRD2 | |
| SCHEMBL10410635 | 0.81 | FFAR4 (0.43) | — | |
| SCHEMBL10409074 | 0.78 | SIGMAR1 (0.57) | SIGMAR1EBPTMEM97BCHEDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4958026-A | HYPOTENSIVE AGENTS | SCHERING AKTIENGESLLSCHAFT (DE) | 1990-09-18 | — | — | US | disclosed |
| EP-0189473-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS. | SCHERING AG (DE) | 1986-08-06 | — | — | EP | disclosed |
| US-4598068-A | Benzylphenyl osides, method of preparation and use therefor | Societe de Recheres Industrielles (FR) | 1986-07-01 | — | — | US | disclosed |
| WO-1986001204-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-02-27 | — | — | WO | disclosed |