SCHEMBL1041399

SCHEMBL1041399

CC(Oc1ccc2ccccc2n1)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.51
PRNP P04156 2/20 0.51
NPSR1 Q6W5P4 2/20 0.51
RXFP1 Q9HBX9 2/20 0.51
KDM4E B2RXH2 2/20 0.51
MAPK10 P53779 1/20 0.51
KMT2A Q03164 2/20 0.49
CYP1A2 P05177 2/20 0.46
GAA P10253 1/20 0.46
CYP2C9 P11712 1/20 0.46
PKM P14618 1/20 0.46
CYP2C19 P33261 1/20 0.46
MGAM O43451 1/20 0.46
PPARG P37231 2/20 0.43
PPARA Q07869 2/20 0.43
ADAMTS4 O75173 1/20 0.43
CNR2 P34972 1/20 0.42
HPGD P15428 1/20 0.42
LMNA P02545 1/20 0.41
NFKB1 P19838 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30946259 0.86 CYP1A2 (0.54) ALDH1A1PRNPNPSR1RXFP1KDM4E
SCHEMBL27258901 0.86 CYP1A2 (0.54) ALDH1A1PRNPNPSR1RXFP1KDM4E
SCHEMBL11501025 0.86 KMT2A (0.54) ALDH1A1PRNPNPSR1RXFP1KDM4E
SCHEMBL11010037 0.86 CYP1A2 (0.54) ALDH1A1PRNPNPSR1RXFP1KDM4E
SCHEMBL11310453 0.82 TSHR (0.56) ALDH1A1PRNPRXFP1KDM4EKMT2A
SCHEMBL6364357 0.79 KDM4E (0.45) ALDH1A1PRNPNPSR1RXFP1KDM4E
SCHEMBL1771919 0.79 TLR8 (0.50) ALDH1A1PRNPNPSR1RXFP1KDM4E
SCHEMBL946359 0.77 CYP1A2 (0.41) ALDH1A1PRNPNPSR1RXFP1KDM4E
SCHEMBL28485533 0.77 NUDT1 (0.46) ALDH1A1PRNPNPSR1RXFP1KDM4E
SCHEMBL27259523 0.76 KDM4E (0.41) ALDH1A1PRNPNPSR1RXFP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7652037-B2 Methods of lowering lipid levels in a mammal CITY OF HOPE (US) 2010-01-26 US claimed
US-20080200502-A1 METHODS OF LOWERING LIPID LEVELS IN A MAMMAL CITY OF HOPE (US) 2008-08-21 US claimed
EP-1682114-A2 METHODS OF LOWERING LIPID LEVELS IN A MAMMAL City of Hope (US) 2006-07-26 EP claimed
US-20050171150-A1 Methods of lowering lipid levels in a mammal CITY OF HOPE (US) 2005-08-04 US claimed
WO-2005044251-A2 METHODS OF LOWERING LIPID LEVELS IN A MAMMAL CITY OF HOPE (US) 2005-05-19 WO claimed
JP-57014508-A None JP disclosed
JP-57093963-A None JP disclosed
JP-56051455-A None JP disclosed
EP-2269601-A1 LR-9, LR-74 and LR-90 for use in treating complications resulting from diabetes City of Hope (US) 2011-01-05 EP disclosed
JP-S5793963-A ALPHA-(2-QUINOLINOXY)PROPIONIC ACID ANILIDE DERIVATIVE, ITS PREPARATION, AND HERBICIDE NISSAN CHEM IND LTD 1982-06-11 JP disclosed
JP-S5714508-A HERBICIDE COMPOSITION FOR PADDY FIELD NISSAN CHEM IND LTD 1982-01-25 JP disclosed
JP-S5651455-A ALPHA-(2-QUINOLINOXY)PROPIONIC ACID DERIVATIVE AND HERBICIDE NISSAN CHEM IND LTD 1981-05-09 JP disclosed