Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | CRAT | P43155 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CPT2 | P23786 | 3/20 | 0.40 |
| ▸ | CPT1A | P50416 | 3/20 | 0.40 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10414328 | 1.00 | MAPT (0.52) | MAPTCRATLMNASMN1; SMN2CPT2 | |
| Hydrochloric Acid SCHEMBL10414327 | 1.00 | MAPT (0.52) | MAPTCRATLMNASMN1; SMN2CPT2 | |
| Hydrochloric Acid SCHEMBL10415560 | 0.83 | CRAT (0.68) | MAPTCRATLMNASMN1; SMN2CPT2 | |
| Hydrochloric Acid SCHEMBL10415559 | 0.83 | CRAT (0.68) | MAPTCRATLMNASMN1; SMN2CPT2 | |
| Hydrochloric Acid SCHEMBL10415561 | 0.83 | CRAT (0.68) | MAPTCRATLMNASMN1; SMN2CPT2 | |
| Hydrochloric Acid SCHEMBL10415557 | 0.81 | MAPT (0.52) | MAPTCRATLMNASMN1; SMN2CPT2 | |
| Hydrochloric Acid SCHEMBL10415552 | 0.81 | MAPT (0.52) | MAPTCRATLMNASMN1; SMN2CPT2 | |
| Hydrochloric Acid SCHEMBL10415563 | 0.80 | MAPT (0.50) | MAPTCRATLMNASMN1; SMN2CPT2 | |
| Hydrochloric Acid SCHEMBL10415566 | 0.80 | MAPT (0.50) | MAPTCRATLMNASMN1; SMN2CPT2 | |
| Hydrochloric Acid SCHEMBL10415565 | 0.80 | MAPT (0.50) | MAPTCRATLMNASMN1; SMN2CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4948534-A | ANTIDIABETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-08-14 | — | — | US | disclosed |
| EP-0127098-B1 | DERIVATIVES OF BETA-AMINO-GAMMA-TRIMETHYLAMMONIO-BUTYRATE, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1989-02-08 | — | — | EP | disclosed |
| US-4767781-A | ANTIDIABETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-08-30 | — | — | US | disclosed |
| EP-0127098-A2 | Derivatives of beta-amino-gamma-trimethylammonio-butyrate, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1984-12-05 | — | — | EP | disclosed |