Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.56 |
| ▸ | STS | P08842 | 6/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.56 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | ESR1 | P03372 | 5/20 | 0.52 |
| ▸ | PGR | P06401 | 2/20 | 0.52 |
| ▸ | AR | P10275 | 2/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17817040 | 0.89 | ESR1 (0.66) | MAPTKMT2AMEN1THRBCYP3A4 | |
| SCHEMBL7992527 | 0.87 | CYP3A4 (0.72) | MAPTKMT2AMEN1THRBCYP3A4 | |
| SCHEMBL9643973 | 0.84 | MAPT (0.55) | MAPTKMT2AMEN1THRBCYP3A4 | |
| SCHEMBL9644054 | 0.84 | MAPT (0.55) | MAPTKMT2AMEN1THRBCYP3A4 | |
| SCHEMBL12473458 | 0.84 | LMNA (0.72) | MAPTCYP3A4STSABCC4CYP2C9 | |
| SCHEMBL544801 | 0.84 | LMNA (0.72) | MAPTCYP3A4STSABCC4CYP2C9 | |
| SCHEMBL6466708 | 0.84 | LMNA (0.72) | MAPTCYP3A4STSABCC4CYP2C9 | |
| SCHEMBL16140032 | 0.84 | LMNA (0.72) | MAPTCYP3A4STSABCC4CYP2C9 | |
| SCHEMBL5679557 | 0.84 | LMNA (0.72) | MAPTCYP3A4STSABCC4CYP2C9 | |
| SCHEMBL544802 | 0.84 | LMNA (0.72) | MAPTCYP3A4STSABCC4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977147-A | CONTRACEPTIVES, ANTITUMOR AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-12-11 | — | — | US | claimed |
| US-4977147-A | CONTRACEPTIVES, ANTITUMOR AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-12-11 | — | — | US | disclosed |
| EP-0320437-A2 | 17-Methylene and 17-ethylidene estratrienes having an oestrogenic activity | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-06-14 | — | — | EP | disclosed |