Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 10/20 | 0.74 |
| ▸ | NAMPT | P43490 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | CA7 | P43166 | 1/20 | 0.63 |
| ▸ | CA9 | Q16790 | 1/20 | 0.63 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10414730 | 0.98 | HPGD (0.72) | HPGDNAMPTSMN1; SMN2HTTLMNA | |
| SCHEMBL30277860 | 0.88 | HPGD (0.73) | HPGDNAMPTSMN1; SMN2HTTLMNA | |
| SCHEMBL4279383 | 0.88 | HPGD (0.73) | HPGDNAMPTSMN1; SMN2HTTLMNA | |
| SCHEMBL13211911 | 0.83 | HTT (0.71) | HPGDNAMPTSMN1; SMN2HTTLMNA | |
| SCHEMBL31396748 | 0.83 | HPGD (0.66) | HPGDNAMPTSMN1; SMN2HTTLMNA | |
| SCHEMBL12459664 | 0.83 | CA1 (0.70) | HPGDNAMPTSMN1; SMN2HTTLMNA | |
| SCHEMBL94624 | 0.83 | HPGD (0.66) | HPGDNAMPTSMN1; SMN2HTTLMNA | |
| SCHEMBL14818002 | 0.83 | HPGD (0.66) | HPGDNAMPTSMN1; SMN2HTTLMNA | |
| SCHEMBL6968133 | 0.81 | MEN1 (0.62) | HPGDNAMPTSMN1; SMN2HTTLMNA | |
| SCHEMBL20389221 | 0.80 | NAMPT (1.00) | NAMPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4945096-A | Treatment of a depressive state with 2-[(4-piperidyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivates | SYNTHELABO (FR) | 1990-07-31 | — | — | US | disclosed |
| US-4885302-A | 2-((4-Piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their application in therapy | SYNTHELABO, 58, RUE DE LA GLACIERE - 75013 PARIS | 1989-12-05 | — | — | US | disclosed |