SCHEMBL10414822

SCHEMBL10414822

C[N+](C)(C)C[C@@H](CC(=O)[O-])NC(=O)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CRAT P43155 1/20 0.58
CPT2 P23786 4/20 0.48
CPT1A P50416 4/20 0.48
CPT1B Q92523 3/20 0.48
CTRB1 P17538 2/20 0.46
CTSG P08311 1/20 0.44
ALDH1A1 P00352 1/20 0.42
RAB9A P51151 1/20 0.42
HPGD P15428 1/20 0.42
SLC22A16 Q86VW1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10414824 1.00 CRAT (0.58) CRATCPT2CPT1ACPT1BCTRB1
SCHEMBL3687565 0.90 CRAT (0.50) CRATCPT2CPT1ACPT1BCTRB1
SCHEMBL3687568 0.90 CRAT (0.50) CRATCPT2CPT1ACPT1BCTRB1
SCHEMBL3687172 0.88 CRAT (0.49) CRAT
SCHEMBL3687169 0.88 CRAT (0.49) CRAT
SCHEMBL3686496 0.86 CRAT (0.47) CRATCPT2CPT1ACPT1BCTRB1
SCHEMBL3686493 0.86 CRAT (0.47) CRATCPT2CPT1ACPT1BCTRB1
SCHEMBL3680338 0.85 ACACB (0.46) CRATCPT2CPT1ACPT1B
SCHEMBL3680337 0.85 ACACB (0.46) CRATCPT2CPT1ACPT1B
Hydrochloric Acid SCHEMBL10415631 0.83 CTRB1 (0.51) CRATCTRB1CTSGALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4948534-A ANTIDIABETIC AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1990-08-14 US disclosed
EP-0127098-B1 DERIVATIVES OF BETA-AMINO-GAMMA-TRIMETHYLAMMONIO-BUTYRATE, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1989-02-08 EP disclosed
US-4767781-A ANTIDIABETIC AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1988-08-30 US disclosed
EP-0127098-A2 Derivatives of beta-amino-gamma-trimethylammonio-butyrate, their production and use Takeda Chemical Industries, Ltd. (JP) 1984-12-05 EP disclosed