CTRB1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL464430	0.66	7/20
SCHEMBL639626	0.71	5/20
SCHEMBL40779	0.58	5/20
SCHEMBL40780	0.58	5/20
SCHEMBL40781	0.58	5/20
SCHEMBL334301	0.57	5/20
SCHEMBL334424	0.57	5/20
SCHEMBL26065	0.50	5/20
SCHEMBL464419	0.48	5/20
SCHEMBL295654	0.45	5/20
SCHEMBL159552	0.42	5/20
SCHEMBL159553	0.42	5/20
SCHEMBL380599	0.42	5/20
SCHEMBL380600	0.42	5/20
SCHEMBL476353	0.42	5/20
SCHEMBL574263	0.42	5/20
SCHEMBL464463	0.40	5/20
SCHEMBL121884	0.38	5/20
SCHEMBL259640	0.62	4/20
SCHEMBL165896	0.61	4/20

Clinical trials — most relevant to CTRB1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Renin-angiotensin-system Blockade on Urinary Free Light Chains in Patients With Type 2 Diabetes Mellitus	PHASE4	COMPLETED
Molecular Mechanisms of Type 2 Diabetes Mellitus	PHASE4	COMPLETED
A Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema	PHASE3	COMPLETED
Efficacy and Safety of GNR-038 vs Berinert® in Patients With Hereditary Angioedema	PHASE2/PHASE3	WITHDRAWN
A Pilot Study of Use of Calcium Channel Blocker to Decrease Inflammation and Pain in Hereditary Pancreatitis	PHASE1/PHASE2	COMPLETED
Comparative Clinical Study to Evaluate the Possible Efficacy and Safety of Oral N-Acetyl Cysteine Versus Rectal Diclofenac in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis	PHASE1/PHASE2	COMPLETED
Genetic Determinism of Epithelial Barrier Defects in Irritable Bowel Syndrome	nan	WITHDRAWN
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Choline Nutritional Status Of Children With Cystic Fibrosis X-Sectional Study	nan	COMPLETED
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD)	nan	COMPLETED
Genetic and Epidemiologic Studies of Premature Coronary Artery Disease - SCOR in Arteriosclerosis	nan	COMPLETED
Markers in Acute Pancreatitis-1	nan	COMPLETED
Surfactant Derived Protocol in Heart Failure	nan	COMPLETED
Blood Test for Early Detection of Breast Cancer Using Todos Medical -Breast 1(TM-B1) Assay	nan	UNKNOWN
Trans Fatty Acids and Cardiovascular Risk Factors	nan	COMPLETED
Pancreatic Exocrine Insufficiency and Pancreatic Enzyme Supplementation in Critically Ill Adult Patients	nan	COMPLETED
Presepsin as a Predictor for Postoperative Complications Following Pancreatic Resection	nan	COMPLETED
Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.	nan	RECRUITING
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy	nan	COMPLETED
CTRP3 and Progranulin in Patients With Coronary Artery Disease	nan	COMPLETED
Post Acute Pancreatitis Pancreatic Exocrine Insufficiency	nan	COMPLETED
Gastrointestinal Study at Orkambi Therapy in CF Patients	nan	UNKNOWN
Defining the Molecular and Physiological Mechanisms of Pancreatic Islet Cell Dysfunction Which Lead to Type 2 Diabetes	nan	COMPLETED
Identifying Maturity-onset Diabetes of the Young in Emirati Patients	nan	NOT_YET_RECRUITING
Exocrine Pancreatic Function Testing in Cystic Fibrosis	nan	UNKNOWN
Genetics of the Metabolic Syndrome in Japanese Americans	nan	COMPLETED
Genetic Modifiers of Cystic Fibrosis: Sibling Study	nan	COMPLETED
Plasma Triglyceride Lipolysis in Multifactorial Chylomicronemia	nan	COMPLETED
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3	nan	COMPLETED
SR-BI and Antiviral Treatment Response in HCV	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CTRB1 binder may also engage these)

Protein	Name	Similarity
P04813	—	1.000	P04813 →
CTRB2	Chymotrypsinogen B2 (EC 3.4.21.1) [Cleaved in	1.000	landscape →
P07338	—	0.999	P07338 →
Q9CR35	—	0.997	Q9CR35 →
P80646	—	0.996	P80646 →
P00767	—	0.993	P00767 →
P00766	—	0.991	P00766 →
P47796	—	0.988	P47796 →
P51588	—	0.984	P51588 →
P29787	—	0.984	P29787 →
P00755	—	0.982	P00755 →
P00759	—	0.981	P00759 →
P00756	—	0.981	P00756 →
P80009	—	0.980	P80009 →
P29786	—	0.979	P29786 →
Q924N9	—	0.978	Q924N9 →
Q27289	—	0.978	Q27289 →
P35037	—	0.978	P35037 →
P15949	—	0.978	P15949 →
Q17025	—	0.978	Q17025 →
P15947	—	0.977	P15947 →
P07647	—	0.977	P07647 →
C6ZDB5	—	0.977	C6ZDB5 →
Q61754	—	0.977	Q61754 →
Q07943	—	0.977	Q07943 →
P32824	—	0.976	P32824 →
P80010	—	0.976	P80010 →
P81286	—	0.976	P81286 →
P15945	—	0.976	P15945 →
Q91508	—	0.976	Q91508 →