Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | ELOVL1 | Q9BW60 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10418593 | 0.88 | ABCB11 (0.72) | ABCB11HDAC6MAPTHTTL3MBTL1 | |
| SCHEMBL10417591 | 0.88 | ABCB11 (0.71) | ABCB11HDAC6MAPTHTTL3MBTL1 | |
| SCHEMBL10417276 | 0.84 | ABCB11 (0.67) | ABCB11HDAC6MAPTHTTL3MBTL1 | |
| SCHEMBL10419334 | 0.84 | ABCB11 (0.67) | ABCB11HDAC6MAPTHTTL3MBTL1 | |
| SCHEMBL10417641 | 0.84 | ABCB11 (0.71) | ABCB11HDAC6MAPTHTTL3MBTL1 | |
| SCHEMBL27671228 | 0.83 | ABCB11 (0.62) | ABCB11HDAC6MAPTHTTL3MBTL1 | |
| SCHEMBL10417256 | 0.81 | ABCB11 (0.76) | ABCB11HDAC6MAPTHTTL3MBTL1 | |
| SCHEMBL9120719 | 0.81 | ABCB11 (0.62) | ABCB11HDAC6MAPTHTTL3MBTL1 | |
| SCHEMBL4880011 | 0.80 | ABCB11 (0.66) | ABCB11HDAC6MAPTHTTL3MBTL1 | |
| SCHEMBL10417200 | 0.80 | ABCB11 (0.62) | ABCB11HDAC6MAPTHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178035-B1 | ANTI-INFLAMMATORY 1,N-DIARYLPYRAZOL-3-AMINES, COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | FISONS plc (GB) | 1990-01-03 | — | — | EP | claimed |
| US-4810719-A | Anti-inflammator 1,n-diarylpyrazol-3-amines | FISONS PLC (GB) | 1989-03-07 | — | — | US | claimed |
| CN-85103468-A | Prepare the method for new compound and new purposes thereof | — | 1986-09-10 | — | — | CN | claimed |
| EP-0178035-A1 | Anti-inflammatory 1,N-diarylpyrazol-3-amines, compositions containing them and processes for their preparation | FISONS plc (GB) | 1986-04-16 | — | — | EP | claimed |
| EP-0178035-B1 | ANTI-INFLAMMATORY 1,N-DIARYLPYRAZOL-3-AMINES, COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | FISONS plc (GB) | 1990-01-03 | — | — | EP | disclosed |
| US-4810719-A | Anti-inflammator 1,n-diarylpyrazol-3-amines | FISONS PLC (GB) | 1989-03-07 | — | — | US | disclosed |
| CN-85103468-A | Prepare the method for new compound and new purposes thereof | — | 1986-09-10 | — | — | CN | disclosed |
| EP-0178035-A1 | Anti-inflammatory 1,N-diarylpyrazol-3-amines, compositions containing them and processes for their preparation | FISONS plc (GB) | 1986-04-16 | — | — | EP | disclosed |