ABCB11

Bile salt export pump · O95342 · ABCB11 on Sugi Atlas →

420,070 patent compounds predicted against ABCB11, 330,244 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Rifamycin (SCHEMBL2320)	1.00	5/20
Fluocortolone (SCHEMBL4644)	0.56	5/20
Flunisolide (SCHEMBL4351)	1.00	4/20
Mometasone Furoate (SCHEMBL4484)	1.00	4/20
Mometasone Furoate (SCHEMBL4568)	1.00	4/20
Clopidogrel (SCHEMBL4769)	1.00	4/20
SCHEMBL4569	0.84	4/20
Paramethasone (SCHEMBL4355)	0.79	4/20
Oxacillin (SCHEMBL3817)	0.79	4/20
SCHEMBL4770	0.77	4/20
Beclomethasone Dipropionate (SCHEMBL5095)	0.69	4/20
Methicillin (SCHEMBL4898)	0.63	4/20
Mevastatin (SCHEMBL1116)	1.00	3/20
Simvastatin (SCHEMBL2471)	1.00	3/20
Simvastatin (SCHEMBL2472)	1.00	3/20
Cloxacillin (SCHEMBL2953)	1.00	3/20
Lovastatin (SCHEMBL3136)	1.00	3/20
Lovastatin (SCHEMBL3137)	1.00	3/20
Floxacillin (SCHEMBL3823)	1.00	3/20
Atorvastatin (SCHEMBL3831)	1.00	3/20

Clinical trials — most relevant to ABCB11 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
BSEP Function Rescue During Childhood Inhereditary Cholestatic Diseases	PHASE2/PHASE3	WITHDRAWN
Efficacy of To Be Marketed (TBM) Cholic Acid Capsules Used to Treat Children With Inborn Errors of Bile Acid Synthesis	PHASE3	COMPLETED
FGFR4 Inhibitor EVER4010001 in Combination With PD-1 Inhibitor Pembrolizumab in Patients With Advanced Solid Tumors	PHASE1/PHASE2	UNKNOWN
Evaluation of Alisporivir for the Treatment of Hospitalised Patients With Infections Due to SARS-CoV-2 (COVID-19)	PHASE2	COMPLETED
A Phase 2 Trial of SCO-101 in Combination With FOLFIRI for Patients With Metastatic Colorectal Cancer (mCRC) With Acquired Resistance to FOLFIRI	PHASE1/PHASE2	UNKNOWN
Influence of Ethnicity and ABCB1 Gene Polymorphism on the Pharmacokinetics of Azithromycin in Healthy Bangladeshi Volunteers	PHASE1	UNKNOWN
Effect of, OAT3, on the Renal Secretion of Cefotaxime	PHASE1	COMPLETED
Phase I Trial of Tariquidar (XR9576) in Combination With Doxorubicin, Vinorelbine, or Docetaxel in Pediatric Patients With Solid Tumors	PHASE1	COMPLETED
Study of AR-67 (Formerly DB-67) in Adult Patients With Refractory or Metastatic Solid Malignancies	PHASE1	COMPLETED
Effect of Non-Alcoholic Steatohepatitis (NASH) on the Pharmacokinetics of 99mTechnetium-Mebrofenin	PHASE1	COMPLETED
Abacavir Pharmacokinetic Study in the Absence/Presence of Darunavir/Ritonavir or Raltegravir in HIV-infected Subjects	PHASE1	COMPLETED
Effect of Obeticholic Acid on Transport of Bile Acids in PBC Examined by 11C-cholyl-sarcosine PET/CT	EARLY_PHASE1	COMPLETED
Bile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population	nan	RECRUITING
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Cholestatic Disorders in Patients with Genetic Liver Disorders and Healthy Individuals	nan	ENROLLING_BY_INVITATION
Secondary Sclerosing Cholangitis in Critically Ill Patients	nan	ACTIVE_NOT_RECRUITING
The Metabolic Profile in Intrahepatic Cholestasis of Pregnancy and Diabetes Mellitus	nan	COMPLETED
Expression of BCRP in Icteric Patients	nan	COMPLETED
the Effect of ABCC2 Genetic Polymorphism on Neurotoxicity in Gastrointestinal Cancer Patients Receiving Oxaliplatin	nan	UNKNOWN
Impact of Genetics on Metformin Pharmacokinetics	nan	COMPLETED
Bile Acid Effects in Fetal Arrhythmia Study	nan	UNKNOWN
Study of CYP2C19 and ALDH3A1 Polymorphisms in Breast Cancer Patients	nan	UNKNOWN
FGF19 in Obstructive Cholestasis: Unveil the Signal	nan	UNKNOWN
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Changes in the Hepatobiliary System in Patients With Primary Biliary Cholangitis Before and After Treatment.	nan	ACTIVE_NOT_RECRUITING
Regulation of Human Intestinal Bile Acid Transport in Health and Disease	nan	COMPLETED
Urobilinogen, Maternal Weight Loss and Impending Parturition at Term	nan	COMPLETED
Pediatric Evaluation and Registry for Liver Cholestasis in Canada	nan	RECRUITING
Genetic Polymorphisms of ABCB11 and ABCB4 in Women With Intrahepatic Cholestasis of Pregnancy (ICP) and in Their First Degree Relatives	nan	UNKNOWN
ADPKD Alterations in Hepatic Transporter Function	nan	COMPLETED
Natural History Study to Determine Drug Metabolism Phenotype and Appropriate Germline Source DNA in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant	nan	RECRUITING
Gastrostomy-Biliary Diversion: Innovative Management for Bile Canalicular Transport Disorders	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ABCB11 binder may also engage these)

Protein	Name	Similarity
Q9QY30	—	1.000	Q9QY30 →
Q9N0V3	—	1.000	Q9N0V3 →
B8K1W2	—	1.000	B8K1W2 →
P21440	—	1.000	P21440 →
P34712	—	0.999	P34712 →
Q9M0M2	—	0.998	Q9M0M2 →
P21449	—	0.998	P21449 →
A0A8B0M670	—	0.997	A0A8B0M670 →
O70127	—	0.997	O70127 →
Q00748	—	0.996	Q00748 →
B5X0E4	—	0.995	B5X0E4 →
Q9LHD1	—	0.995	Q9LHD1 →
P21448	—	0.994	P21448 →
Q8LPK2	—	0.994	Q8LPK2 →
P06795	—	0.993	P06795 →
Q9C8G9	—	0.993	Q9C8G9 →
Q9C7F8	—	0.993	Q9C7F8 →
Q4WTT9	—	0.992	Q4WTT9 →
P21447	—	0.992	P21447 →
Q9C7F2	—	0.992	Q9C7F2 →
P23174	—	0.991	P23174 →
Q9LJX0	—	0.991	Q9LJX0 →
Q08201	—	0.991	Q08201 →
Q9LSJ8	—	0.991	Q9LSJ8 →
Q2M3G0	—	0.991	Q2M3G0 →
P43245	—	0.990	P43245 →
Q9FWX7	—	0.990	Q9FWX7 →
Q9FHF1	—	0.990	Q9FHF1 →
F2RP52	—	0.990	F2RP52 →
P16877	—	0.989	P16877 →