Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 15/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.63 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.59 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.59 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.59 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.59 |
| ▸ | ATXN2 | Q99700 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL107319 | 0.93 | GRIN2D (0.61) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL171984 | 0.88 | ENPP2 (0.63) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL106235 | 0.87 | ENPP2 (0.67) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3047541 | 0.84 | ENPP2 (0.72) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL171944 | 0.81 | GRIN2D (0.61) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL105007 | 0.81 | ENPP2 (0.60) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3054811 | 0.78 | ENPP2 (1.00) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3055653 | 0.78 | ENPP2 (0.65) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL105939 | 0.75 | ENPP2 (0.71) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1907303 | 0.75 | ENPP2 (0.67) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426106-B1 | Piperidine and Piperazine derivatives for the treatment of tumours | MERCK PATENT GMBH (DE) | 2013-07-31 | — | — | EP | claimed |
| EP-2426106-A1 | Piperidine and Piperazine derivatives for the treatment of tumours | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | claimed |
| EP-2426106-B1 | Piperidine and Piperazine derivatives for the treatment of tumours | MERCK PATENT GMBH (DE) | 2013-07-31 | — | — | EP | disclosed |
| EP-2426106-A1 | Piperidine and Piperazine derivatives for the treatment of tumours | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |