Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 7/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 11/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7545405 | 0.91 | MEN1 (0.55) | MEN1NR1I2KMT2ATHRBP2RX7 | |
| SCHEMBL8603426 | 0.87 | KMT2A (0.54) | MEN1NR1I2KMT2ATHRBP2RX7 | |
| SCHEMBL10395321 | 0.86 | KMT2A (0.50) | MEN1NR1I2KMT2ATHRBP2RX7 | |
| SCHEMBL10421420 | 0.82 | KMT2A (0.57) | MEN1NR1I2KMT2ATHRBP2RX7 | |
| SCHEMBL6479147 | 0.81 | MEN1 (0.54) | MEN1NR1I2KMT2ATHRBP2RX7 | |
| SCHEMBL10419884 | 0.79 | MEN1 (0.47) | MEN1NR1I2KMT2ATHRBP2RX7 | |
| SCHEMBL10667155 | 0.78 | MEN1 (0.50) | MEN1NR1I2KMT2ATHRBP2RX7 | |
| SCHEMBL10420895 | 0.78 | MEN1 (0.55) | MEN1NR1I2KMT2ATHRBP2RX7 | |
| SCHEMBL10670462 | 0.77 | MEN1 (0.50) | MEN1NR1I2KMT2ATHRBP2RX7 | |
| SCHEMBL10420835 | 0.77 | MEN1 (0.49) | MEN1NR1I2KMT2ATHRBP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170316-B1 | ALPHA-ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN-2(3H)-YL)BENZENEACETONITRILES | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-05-30 | — | — | EP | disclosed |
| US-4778887-A | ANTIPROTOZOA AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-10-18 | — | — | US | disclosed |
| US-4631278-A | Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-12-23 | — | — | US | disclosed |
| EP-0170316-A2 | alpha-Aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitriles | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-02-05 | — | — | EP | disclosed |