SCHEMBL10420596

SCHEMBL10420596

O=C(O)c1ccc(Oc2ccc(C(=O)O)c3ccccc23)c2ccccc12

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC25B P30305 2/20 0.57
NR4A1 P22736 1/20 0.50
NR4A2 P43354 1/20 0.50
NR4A3 Q92570 1/20 0.50
PLK1 P53350 1/20 0.47
HTT P42858 1/20 0.47
WDR5 P61964 1/20 0.47
ALDH1A1 P00352 3/20 0.46
ALOX15 P16050 1/20 0.46
HPGDS O60760 1/20 0.46
CYP2C9 P11712 3/20 0.46
HPGD P15428 3/20 0.46
HSD17B10 Q99714 3/20 0.46
KDM4E B2RXH2 2/20 0.46
TSHR P16473 2/20 0.46
LDHA P00338 1/20 0.46
ALOX12 P18054 1/20 0.46
ATIC P31939 1/20 0.46
HIF1A Q16665 1/20 0.45
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14204728 0.90 CDC25B (0.53) CDC25BNR4A1NR4A2NR4A3PLK1
SCHEMBL7536268 0.89 NR4A1 (0.59) CDC25BNR4A1NR4A2NR4A3WDR5
SCHEMBL28828357 0.88 CXCL8 (0.50) CDC25BNR4A1NR4A2NR4A3PLK1
SCHEMBL28066258 0.88 HTT (0.68) CDC25BPLK1HTTALDH1A1HPGDS
SCHEMBL28191976 0.84 CDC25B (0.48) CDC25BNR4A1NR4A2NR4A3PLK1
SCHEMBL30838412 0.84 NR4A1 (0.65) CDC25BNR4A1NR4A2NR4A3WDR5
SCHEMBL29406630 0.84 NR4A1 (0.65) CDC25BNR4A1NR4A2NR4A3WDR5
SCHEMBL30838413 0.84 NR4A1 (0.65) CDC25BNR4A1NR4A2NR4A3WDR5
SCHEMBL28798 0.84 NR4A1 (0.65) CDC25BNR4A1NR4A2NR4A3WDR5
SCHEMBL4469856 0.84 CDC25B (0.78) CDC25BPLK1HTTALDH1A1HPGDS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4914181-A AUTOPHOTOCROSSLINKABLE; BASED ON CARBONYL-CONTAINING TETRACARBOXYLIC ACIDS AND ACYCLIC OR CARBO DIAMINES; PROTECTIVE COATINGS; PHOTORESISTS; VARNISHES; LACQUERS SEMICONDUCTORS CIBA-GEIGY CORPORATION (US) 1990-04-03 US disclosed
US-4914182-A AUTOPHOTOCROSSLINKABLE; PROTECTIVE FILMS, PHOTOGRAPHIC RELIEF IMAGES CIBA-GEIGY CORPORATION (US) 1990-04-03 US disclosed
US-4698295-A AUTOMATIC PHOTOCROSSLINKING CIBA-GEIGY CORPORATION (US) 1987-10-06 US disclosed