Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10422616 | 0.82 | RAB9A (0.56) | RAB9AKDM4ENPC1MAPTLMNA | |
| SCHEMBL10422617 | 0.82 | RAB9A (0.56) | RAB9AKDM4ENPC1MAPTLMNA | |
| SCHEMBL6585906 | 0.81 | CYSLTR1 (0.62) | CYSLTR2CYSLTR1FFAR1PLAU | |
| SCHEMBL10479271 | 0.79 | RAB9A (0.63) | RAB9AKDM4ENPC1MAPTLMNA | |
| SCHEMBL28438758 | 0.77 | RAB9A (0.68) | RAB9AKDM4ENPC1MAPTLMNA | |
| SCHEMBL28438756 | 0.77 | RAB9A (0.68) | RAB9AKDM4ENPC1MAPTLMNA | |
| SCHEMBL16971027 | 0.76 | RAB9A (0.62) | RAB9AKDM4ENPC1MAPTLMNA | |
| SCHEMBL10895807 | 0.76 | RAB9A (0.62) | RAB9AKDM4ENPC1MAPTLMNA | |
| SCHEMBL5613168 | 0.76 | MAOB (0.54) | RAB9AKDM4ENPC1LMNAALDH1A1 | |
| SCHEMBL9031944 | 0.75 | CYSLTR1 (0.66) | CYSLTR2CYSLTR1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4918081-A | Quinoline derivatives and use thereof as antagonists of leukotriene d4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-17 | — | — | US | disclosed |
| WO-1989012629-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-12-28 | — | — | WO | disclosed |