Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 12/20 | 0.55 |
| ▸ | CYSLTR2 | Q9NS75 | 11/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828490 | 0.96 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL10421917 | 0.92 | CYSLTR2 (0.59) | CYSLTR1CYSLTR2MAPK1GPBAR1TP53 | |
| SCHEMBL10420411 | 0.92 | CYSLTR2 (0.51) | CYSLTR1CYSLTR2 | |
| SCHEMBL10421959 | 0.92 | CYSLTR1 (0.56) | CYSLTR1CYSLTR2MAPK1GPBAR1TP53 | |
| SCHEMBL9828588 | 0.90 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2 | |
| SCHEMBL10422056 | 0.90 | CYSLTR1 (0.56) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL9829331 | 0.87 | CYSLTR1 (0.49) | CYSLTR1CYSLTR2 | |
| SCHEMBL7008709 | 0.87 | CYSLTR1 (0.57) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL10422013 | 0.87 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2MAPK1GPBAR1TP53 | |
| SCHEMBL10421067 | 0.86 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2MAPK1GPBAR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |