Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9438275 | 0.85 | LMNA (0.46) | LMNAPTPN1MEN1CYP3A4ALOX15 | |
| SCHEMBL1417481 | 0.85 | LMNA (0.46) | LMNA | |
| SCHEMBL1417606 | 0.85 | LMNA (0.46) | LMNA | |
| SCHEMBL1627954 | 0.85 | LMNA (0.46) | LMNA | |
| SCHEMBL1417818 | 0.85 | LMNA (0.46) | LMNA | |
| SCHEMBL2487167 | 0.85 | LMNA (0.46) | LMNA | |
| SCHEMBL1417485 | 0.85 | LMNA (0.46) | LMNA | |
| SCHEMBL1417497 | 0.85 | LMNA (0.46) | LMNA | |
| SCHEMBL1417627 | 0.85 | LMNA (0.46) | LMNA | |
| SCHEMBL1417248 | 0.85 | LMNA (0.46) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4980371-A | TREATMENT OF HIV INFECTIONS/LEUKEMIA; ANTITUMOR AGENTS, ANTICARCINOGENIC AGENTS | MERRELL DOW PHARMACEUTICALS (US) | 1990-12-25 | — | — | US | disclosed |
| EP-0374886-A2 | Antiretroviral furan ketones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-06-27 | — | — | EP | disclosed |