Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10422201 | 1.00 | KCNH2 (0.54) | KCNH2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL10422207 | 0.97 | KCNH2 (0.52) | KCNH2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL10422205 | 0.97 | KCNH2 (0.52) | KCNH2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL10422225 | 0.93 | KCNH2 (0.48) | KCNH2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL10422226 | 0.93 | KCNH2 (0.48) | KCNH2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL10423890 | 0.89 | SIGMAR1 (0.60) | KCNH2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL10423891 | 0.89 | SIGMAR1 (0.60) | KCNH2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL10422089 | 0.88 | HTR2A (0.49) | KCNH2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL10422088 | 0.88 | HTR2A (0.49) | KCNH2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL10423546 | 0.88 | KCNH2 (0.58) | KCNH2HTR2AHTR2CHTR2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4931443-A | ANTIPSYCHOTIC AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1990-06-05 | — | — | US | disclosed |
| EP-0288575-A1 | PIPERAZINE COMPOUNDS AND THEIR MEDICINAL USE | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1988-11-02 | — | — | EP | disclosed |