Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.91 |
| ▸ | ARG2 | P78540 | 4/20 | 0.55 |
| ▸ | ARG1 | P05089 | 3/20 | 0.55 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.54 |
| ▸ | NOS2 | P35228 | 6/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 4/20 | 0.53 |
| ▸ | NOS3 | P29474 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL15286920 | 1.00 | GSR (0.91) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL28200568 | 0.98 | GSR (0.87) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL28200566 | 0.98 | GSR (0.87) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL5060018 | 0.95 | GSR (0.91) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL31644218 | 0.95 | GSR (0.91) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL4641859 | 0.95 | GSR (0.91) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL31039861 | 0.95 | GSR (0.91) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL1645 | 0.95 | GSR (1.00) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL12867528 | 0.95 | GSR (1.00) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL7343 | 0.95 | GSR (1.00) | GSRARG2ARG1RNPEPNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013142969-A1 | URETHANES AND UREAS AND PROCESSES | GAO JIAN PING (CA) | 2013-10-03 | — | — | WO | claimed |
| CN-116348148-A | Engineered extracellular vesicles exhibiting enhanced pharmacokinetics | 医福斯治疗有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-109311827-A | Prostate specific membrane antigen targeted high affinity agents for intracavitary radiotherapy of prostate cancer | 约翰霍普金斯大学 | 2019-02-05 | — | — | CN | disclosed |
| US-9644221-B2 | Method of producing chemical by continuous fermentation and continuous fermentation apparatus | TORAY INDUSTRIES, INC. (JP) | 2017-05-09 | — | — | US | disclosed |
| EP-2837687-B1 | METHOD FOR PRODUCING CHEMICAL BY MEANS OF CONTINUOUS FERMENTATION AND CONTINUOUS FERMENTATION DEVICE | TORAY INDUSTRIES (JP) | 2017-02-22 | — | — | EP | disclosed |
| US-20150056665-A1 | METHOD OF PRODUCING CHEMICAL BY CONTINUOUS FERMENTATION AND CONTINUOUS FERMENTATION APPARATUS | TORAY INDUSTRIES, INC. (JP) | 2015-02-26 | — | — | US | disclosed |
| EP-2837687-A1 | METHOD FOR PRODUCING CHEMICAL BY MEANS OF CONTINUOUS FERMENTATION AND CONTINUOUS FERMENTATION DEVICE | Toray Industries, Inc. (JP) | 2015-02-18 | — | — | EP | disclosed |
| CN-104284918-A | Urethanes and ureas and processes | GAO JIANPING | 2015-01-14 | — | — | CN | disclosed |
| WO-2013142969-A1 | URETHANES AND UREAS AND PROCESSES | GAO JIAN PING (CA) | 2013-10-03 | — | — | WO | disclosed |
| EP-1480941-B1 | UREA DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS | AMBRILIA BIOPHARMA INC (CA) | 2011-01-26 | — | — | EP | disclosed |
| EP-1480941-A2 | UREA DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS | Procyon Biopharma Inc. (CA) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003074467-A2 | UREA DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS | PROCYON BIOPHARMA INC. (CA) | 2003-09-12 | — | — | WO | disclosed |
| US-6528532-B1 | Benzenesulfonamide group | PHARMACOR INC. (CA) | 2003-03-04 | — | — | US | disclosed |