Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | SI | P14410 | 1/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.44 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4661591 | 0.85 | GAA (0.50) | GAAMGAMSIMGAM2GRIK1 | |
| SCHEMBL30904961 | 0.82 | GRIK1 (0.48) | GAAMGAMSIMGAM2GRIK1 | |
| SCHEMBL10382305 | 0.82 | GRIK1 (0.48) | GAAMGAMSIMGAM2GRIK1 | |
| SCHEMBL27781924 | 0.80 | GAA (0.58) | GAAMGAMSIMGAM2GRIK1 | |
| SCHEMBL28601595 | 0.77 | GAA (0.54) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL13293249 | 0.77 | GAA (0.54) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL3504490 | 0.77 | GAA (0.54) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL5879637 | 0.77 | GAA (0.54) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL14349108 | 0.76 | GRIK1 (0.43) | GAAGRIK1GRIA2GRIA4GRIK3 | |
| SCHEMBL2637977 | 0.76 | NR1H4 (0.45) | ALDH1A1LMNAL3MBTL1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4918105-A | Novel compounds with collagenase-inhibiting activity, a process for their preparation and pharmaceutical compositions in which these compounds are present | SA LABORATOIRE ROGER BELLON (FR) | 1990-04-17 | — | — | US | disclosed |