Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | SI | P14410 | 1/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046565 | 0.85 | SMN1; SMN2 (0.44) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL10423902 | 0.85 | GAA (0.50) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL2637984 | 0.82 | NR1H4 (0.45) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL2637977 | 0.82 | NR1H4 (0.45) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL11031995 | 0.80 | GAA (0.58) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL5608028 | 0.80 | GAA (0.58) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL5963310 | 0.79 | ALDH1A1 (0.43) | GAAALDH1A1TRPA1NPSR1GLO1 | |
| SCHEMBL28448521 | 0.79 | NPSR1 (0.38) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL5963307 | 0.79 | ALDH1A1 (0.43) | GAAALDH1A1TRPA1NPSR1GLO1 | |
| SCHEMBL4661706 | 0.79 | GAA (0.47) | GAAMGAMSIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392638-B1 | PROCESS FOR PREPARING ALKYLIDENE SUBSTITUTED SUCCINIC ACID ESTERS | BASELL POLIOLEFINE ITALIA SRL (IT) | 2016-12-14 | — | — | EP | disclosed |
| EP-1527039-B1 | PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES | BASELL POLIOLEFINE SRL (IT) | 2008-12-24 | — | — | EP | disclosed |
| US-7465821-B2 | Process for preparing alkylidene-substituted-1, 4-dions derivatives | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2008-12-16 | — | — | US | disclosed |
| US-7399879-B2 | Process for preparing alkylidene-substituted-1,4-dions derivatives | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2008-07-15 | — | — | US | disclosed |
| US-6914153-B2 | Process for preparing alkylidene substituted succinic acid esters | BASSELL POLIOLEFINE ITALIA S.P.A. (IT) | 2005-07-05 | — | — | US | disclosed |
| US-20050113599-A1 | Process for preparing alkylidene-substituted -1, 4-dions derivatives | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2005-05-26 | — | — | US | disclosed |
| EP-1527039-A1 | PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES | Basell Poliolefine Italia S.P.A. (IT) | 2005-05-04 | — | — | EP | disclosed |
| EP-1527040-A1 | PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES | Basel Poliolefine Italia SpA (IT) | 2005-05-04 | — | — | EP | disclosed |
| US-20050080290-A1 | Process for preparing alkylidene-substituted-1, 4-dions derivatives | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2005-04-14 | — | — | US | disclosed |
| EP-1392638-A1 | PROCESS FOR PREPARING ALKYLIDENE SUBSTITUTED SUCCINIC ACID ESTERS | Basell Poliolefine Italia S.p.A. (IT) | 2004-03-03 | — | — | EP | disclosed |
| WO-2004014838-A1 | PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2004-02-19 | — | — | WO | disclosed |
| WO-2004014839-A1 | PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES | BASEL POLIOLEFINE ITALIA S.P.A. (IT) | 2004-02-19 | — | — | WO | disclosed |
| US-20030181743-A1 | Process for preparing alkylidene substituted succinic acid esters | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2003-09-25 | — | — | US | disclosed |
| WO-2002098837-A1 | PROCESS FOR PREPARING ALKYLIDENE SUBSTITUTED SUCCINIC ACID ESTERS | BASELL POLIOLEFINE ITALIA S.P.A (IT) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113599-A1 | Process for preparing alkylidene-substituted -1, 4-dions derivatives | KCNJ4, NR3C2, NR4A2 | GAA 4586/4885MGAM 3919/4885SI 3511/4885 |
| US-20030181743-A1 | Process for preparing alkylidene substituted succinic acid esters | OGDH, SCO2, SUCNR1 | GAA 3356/4885MGAM 776/4885SI 32/4885 |
| US-20050080290-A1 | Process for preparing alkylidene-substituted-1, 4-dions derivatives | RTN4, NR4A2, NR3C2 | GAA 4844/4885MGAM 4851/4885SI 4384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.