Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | PAM | P19021 | 1/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL670712 | 0.87 | HPGD (0.50) | CYP1A2HPGDCYP2C9CYP2C19AKR1B1 | |
| SCHEMBL21328440 | 0.85 | CYP1A2 (0.59) | CYP1A2HPGDCYP2C9FFAR1KDM4E | |
| SCHEMBL14273063 | 0.83 | CYP1A2 (0.73) | CYP1A2HPGDCYP2C9FFAR1KDM4E | |
| SCHEMBL8631418 | 0.83 | POLB (0.53) | HPGDCYP2C9CYP2C19AKR1B1TDP1 | |
| SCHEMBL11533963 | 0.83 | CYP1A2 (0.58) | CYP1A2HPGDCYP2C9CYP2C19FFAR1 | |
| SCHEMBL4828911 | 0.82 | AKR1B1 (0.59) | CYP1A2HPGDCYP2C9CYP2C19AKR1B1 | |
| SCHEMBL4438683 | 0.82 | CYP2C9 (0.69) | HPGDCYP2C9CYP2C19AKR1B1TDP1 | |
| SCHEMBL14273050 | 0.80 | CYP1A2 (0.54) | CYP1A2HPGDCYP2C9FFAR1KDM4E | |
| SCHEMBL711355 | 0.78 | CYP2C9 (0.56) | HPGDCYP2C9CYP2C19AKR1B1TDP1 | |
| SCHEMBL4832670 | 0.78 | CYP2C9 (0.56) | CYP1A2HPGDCYP2C9CYP2C19AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4935441-A | Flavene and thioflavene derivates, processes for their manufacture, pharmaceutical preparations that contain such compounds, and the use of the latter | ZYMA SA (CH) | 1990-06-19 | — | — | US | disclosed |
| EP-0139615-B1 | FLAVENE AND THIOFLAVENE DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SUCH COMPOUNDS, AND THE USE OF THE LATTER | Zyma SA (CH) | 1989-04-19 | — | — | EP | disclosed |
| EP-0139615-A2 | Flavene and thioflavene derivatives, processes for their manufacture, pharmaceutical preparations that contain such compounds, and the use of the latter | Zyma SA (CH) | 1985-05-02 | — | — | EP | disclosed |