Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.59 |
| ▸ | MMP2 | P08253 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | MMP12 | P39900 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CXCL8 | P10145 | 5/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3765157 | 0.90 | HPGD (0.78) | CYP2C9HPGDCYP2C19AKR1B1MMP2 | |
| SCHEMBL4441106 | 0.89 | CYP2C9 (0.58) | CYP2C9HPGDCYP2C19AKR1B1MMP2 | |
| SCHEMBL10937060 | 0.89 | CYP2C9 (0.67) | CYP2C9HPGDCYP2C19AKR1B1MMP2 | |
| SCHEMBL5658529 | 0.88 | TDP1 (0.69) | CYP2C9HPGDCYP2C19AKR1B1MMP2 | |
| SCHEMBL4828911 | 0.87 | AKR1B1 (0.59) | CYP2C9HPGDCYP2C19AKR1B1MMP2 | |
| SCHEMBL4438686 | 0.86 | HPGD (0.55) | CYP2C9HPGDCYP2C19AKR1B1MMP2 | |
| SCHEMBL6792300 | 0.85 | MMP2 (0.60) | CYP2C9HPGDCYP2C19AKR1B1MMP2 | |
| SCHEMBL8228112 | 0.84 | MMP2 (0.76) | CYP2C9HPGDCYP2C19AKR1B1MMP2 | |
| SCHEMBL6933325 | 0.84 | CYP2C9 (0.74) | CYP2C9HPGDCYP2C19AKR1B1MMP2 | |
| SCHEMBL10938090 | 0.83 | PDE7A (0.54) | CYP2C9HPGDCYP2C19AKR1B1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8933195-B2 | Histone deacetylase inhibitors and synthetic method thereof and use thereof in manufacture of medicaments | NANJING YOKO BIOMEDICAL R & D LTD. (CN) | 2015-01-13 | — | — | US | disclosed |
| US-20140243501-A1 | HISTONE DEACETYLASE INHIBITORS AND SYNTHETIC METHOD THEREOF AND USE THEREOF IN MANUFACTURE OF MEDICAMENTS | NANJING YOKO BIOMEDICAL R & D LTD. [CN/CN] (CN) | 2014-08-28 | — | — | US | disclosed |
| CN-101622227-A | Biaryl and biheteroaryl compounds useful in treating iron disorders | XENON PHARMACEUTICALS INC | 2010-01-06 | — | — | CN | disclosed |
| EP-2061754-A1 | BIARYL AND BIHETEROARYL COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008115999-A1 | BIARYL AND BIHETEROARYL COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-25 | — | — | WO | disclosed |
| US-20080234384-A1 | BIARYL AND BIHETEROARYL COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234384-A1 | BIARYL AND BIHETEROARYL COMPOUNDS USEFUL IN TREATING IRON DISORDERS | FECH, SLC10A1, SLC40A1 | CYP2C9 228/4885HPGD 575/4885CYP2C19 282/4885 |
| US-20140243501-A1 | HISTONE DEACETYLASE INHIBITORS AND SYNTHETIC METHOD THEREOF AND USE THEREOF IN MANUFACTURE OF MEDICAMENTS | HDAC1, HDAC11, HDAC2 | CYP2C9 3186/4885HPGD 1152/4885CYP2C19 3358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.