Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 6/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10424679 | 0.89 | HMGCR (0.63) | HMGCR | |
| SCHEMBL9871063 | 0.88 | HMGCR (0.74) | HMGCR | |
| SCHEMBL10424692 | 0.88 | HMGCR (0.74) | HMGCR | |
| SCHEMBL10424680 | 0.85 | HMGCR (0.79) | HMGCR | |
| SCHEMBL10424089 | 0.82 | HMGCR (0.82) | HMGCR | |
| SCHEMBL9022876 | 0.79 | HMGCR (0.81) | HMGCR | |
| SCHEMBL10424071 | 0.77 | HMGCR (0.78) | HMGCR | |
| SCHEMBL10425481 | 0.77 | HMGCR (0.79) | HMGCR | |
| SCHEMBL10425480 | 0.74 | HMGCR (0.88) | HMGCR | |
| SCHEMBL9872785 | 0.73 | HMGCR (1.00) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4925852-A | TREATMENT OR PROPHYLAXIS OF ARTERIOSCLEROSIS OR HYPERCHOLESTEROLEMIA | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-15 | — | — | US | disclosed |
| EP-0307342-A2 | 3-Demethyl-4-fluoro-mevalonic-acid derivatives, process for their preparation, pharmaceutical preparations based on those compounds, their use and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-03-15 | — | — | EP | disclosed |