Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 11/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10424692 | 1.00 | HMGCR (0.74) | HMGCR | |
| SCHEMBL10424071 | 0.89 | HMGCR (0.78) | HMGCR | |
| SCHEMBL10425482 | 0.88 | HMGCR (0.59) | HMGCR | |
| SCHEMBL10425481 | 0.88 | HMGCR (0.79) | HMGCR | |
| SCHEMBL10554029 | 0.85 | HMGCR (0.72) | HMGCR | |
| SCHEMBL9872785 | 0.85 | HMGCR (1.00) | HMGCR | |
| SCHEMBL10512078 | 0.82 | HMGCR (0.49) | HMGCR | |
| SCHEMBL9872045 | 0.82 | HMGCR (1.00) | HMGCR | |
| SCHEMBL9872047 | 0.82 | HMGCR (1.00) | HMGCR | |
| SCHEMBL10424011 | 0.81 | HMGCR (0.69) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997837-A | Enzyme inhibitors | WARNER-LAMBERT COMPANY (US) | 1991-03-05 | — | — | US | disclosed |
| US-4906624-A | 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis | WARNER-LAMBERT COMPANY (US) | 1990-03-06 | — | — | US | disclosed |
| EP-0306929-A2 | 6-[[(Substituted)pyridin-3-YL]alkyl]-and alkenyl]-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis | WARNER-LAMBERT COMPANY (US) | 1989-03-15 | — | — | EP | disclosed |