⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976035 | 0.79 | CA2 (0.33) | — | |
| SCHEMBL193624 | 0.75 | KDM4E (0.35) | — | |
| SCHEMBL13560816 | 0.75 | — | — | |
| Guanidine SCHEMBL5503970 | 0.74 | KDM4E (0.53) | — | |
| Guanidine SCHEMBL2136925 | 0.74 | — | — | |
| Guanidine SCHEMBL19458437 | 0.74 | KDM4E (0.53) | — | |
| SCHEMBL14583610 | 0.73 | — | — | |
| SCHEMBL2565947 | 0.73 | — | — | |
| Biguanide SCHEMBL9665553 | 0.73 | KDM4E (0.46) | — | |
| SCHEMBL19458436 | 0.73 | KDM4E (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109111376-A | A kind of 2,5- double deoxidation strepto- amine derivative and its application | 四川医立特生物医药有限公司 | 2019-01-01 | — | — | CN | disclosed |
| CN-104777301-B | Zanamivir phosphonate congeners with anti-influenza activity and determination of oseltamivir susceptibility of influenza viruses | 中央研究院 | 2018-04-20 | — | — | CN | disclosed |
| EP-2776471-A1 | STABLE PEPTIDE-BASED FURIN INHIBITORS | Socpra Sciences Santé Et Humaines S.E.C. (CA) | 2014-09-17 | — | — | EP | disclosed |
| EP-2751141-A1 | STABLE PEPTIDE-BASED PACE4 INHIBITORS | Socpra Sciences Santé Et Humaines S.E.C. (CA) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013029182-A1 | STABLE PEPTIDE-BASED FURIN INHIBITORS | SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C. (CA) | 2013-03-07 | — | — | WO | disclosed |
| WO-2013029180-A1 | STABLE PEPTIDE-BASED PACE4 INHIBITORS | SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C. (CA) | 2013-03-07 | — | — | WO | disclosed |
| US-8357673-B2 | 4-arylazo-3,5-diamino-pyrazole compounds and use thereof | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2013-01-22 | — | — | US | disclosed |
| US-8034932-B2 | Hydroxy-3-methylglutaryl/3-/ coenzyme A reductase inhibitor; anticholesterol agents;dyslipidemia; chemical intermediate for rosuvastatin | ASTRAZENECA UK LIMITED (GB) | 2011-10-11 | — | — | US | disclosed |
| EP-2361906-A1 | Process for preparing rosuvastatin | AstraZeneca UK Limited (GB) | 2011-08-31 | — | — | EP | disclosed |
| US-20100144698-A1 | SUBSTITUTED AZETIDINONES | DAIAMED (US) | 2010-06-10 | — | — | US | disclosed |
| US-4904792-A | N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds | ELI LILLY AND COMPANY (US) | 1990-02-27 | — | — | US | disclosed |
| US-4760075-A | Miticides | ELI LILLY AND COMPANY (US) | 1988-07-26 | — | — | US | disclosed |
| EP-0091220-B1 | THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |
| EP-0049618-B1 | IMPROVEMENTS IN OR RELATING TO 2,4-DISUBSTITUTED THIAZOLE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1985-08-14 | — | — | EP | disclosed |
| US-4474794-A | N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds | ELI LILLY AND COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0002930-B1 | AMINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1983-12-14 | — | — | EP | disclosed |
| EP-0091220-A2 | Thiazole derivatives, process for their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1983-10-12 | — | — | EP | disclosed |
| US-4382090-A | N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds | ELI LILLY AND COMPANY (US) | 1983-05-03 | — | — | US | disclosed |
| US-4375547-A | ANTIHISTAMINES, 'I RECEPTOR ANTAGONISTS, ANTISECRETORY AGENTS | ELI LILLY AND COMPANY (US) | 1983-03-01 | — | — | US | disclosed |
| EP-0049618-A1 | Improvements in or relating to 2,4-disubstituted thiazole derivatives | ELI LILLY AND COMPANY (US) | 1982-04-14 | — | — | EP | disclosed |