Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 8/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PGR | P06401 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | AR | P10275 | 6/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.49 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10427869 | 1.00 | CYP3A4 (0.55) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10427817 | 0.90 | HIF1A (0.56) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10427768 | 0.90 | HIF1A (0.56) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10625979 | 0.90 | CYP3A4 (0.62) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10625985 | 0.90 | CYP3A4 (0.62) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10356238 | 0.88 | PGR (0.56) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10427757 | 0.88 | PGR (0.56) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10356236 | 0.88 | PGR (0.56) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10427898 | 0.84 | PGR (0.66) | CYP3A4HIF1ACYP2C9ALDH1A1HSD17B10 | |
| SCHEMBL10427880 | 0.84 | PGR (0.66) | CYP3A4HIF1ACYP2C9ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0100874-B1 | 6,16-DIMETHYL CORTICOIDS, THEIR PREPARATION AND THEIR USE | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-03-07 | — | — | EP | claimed |
| US-4701451-A | Novel 6,16-dimethylcorticoids their preparation and use | SCHERING AKTIENGESELLSCHAFT (DE) | 1987-10-20 | — | — | US | claimed |
| EP-0100874-A2 | 6,16-Dimethyl corticoids, their preparation and their use | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-02-22 | — | — | EP | claimed |
| US-4701451-A | Novel 6,16-dimethylcorticoids their preparation and use | SCHERING AKTIENGESELLSCHAFT (DE) | 1987-10-20 | — | — | US | disclosed |
| US-4555507-A | Novel 6, 16-dimethylcorticoids, their preparation and use | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-11-26 | — | — | US | disclosed |