Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 8/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 7/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 4/20 | 0.48 |
| ▸ | AR | P10275 | 3/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MLNR | O43193 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10427781 | 1.00 | CYP3A4 (0.54) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10892103 | 0.93 | HIF1A (0.55) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10892119 | 0.93 | HIF1A (0.55) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL11126161 | 0.92 | PGR (0.54) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL11126157 | 0.92 | PGR (0.54) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL11126155 | 0.92 | PGR (0.54) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10427811 | 0.91 | HIF1A (0.54) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10427795 | 0.91 | HIF1A (0.54) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10623142 | 0.91 | CYP3A4 (0.61) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR | |
| SCHEMBL10623134 | 0.91 | CYP3A4 (0.61) | CYP3A4HIF1ACYP2C9ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0100874-B1 | 6,16-DIMETHYL CORTICOIDS, THEIR PREPARATION AND THEIR USE | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-03-07 | — | — | EP | claimed |
| EP-0100874-A2 | 6,16-Dimethyl corticoids, their preparation and their use | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-02-22 | — | — | EP | claimed |
| US-4555507-A | Novel 6, 16-dimethylcorticoids, their preparation and use | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-11-26 | — | — | US | disclosed |