Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.90 |
| ▸ | POLB | P06746 | 1/20 | 0.90 |
| ▸ | HPGD | P15428 | 1/20 | 0.90 |
| ▸ | HK1 | P19367 | 1/20 | 0.90 |
| ▸ | APEX1 | P27695 | 1/20 | 0.90 |
| ▸ | RECQL | P46063 | 1/20 | 0.90 |
| ▸ | BLM | P54132 | 1/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.90 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.90 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.87 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9147626 | 0.88 | CHRM2 (0.88) | KMT2ACHRM2 | |
| SCHEMBL13574310 | 0.87 | CYP3A4 (0.87) | KDM4EALDH1A1POLBHPGDHK1 | |
| SCHEMBL9627022 | 0.86 | HEXA (0.69) | KDM4EALDH1A1POLBHPGDHK1 | |
| SCHEMBL9625295 | 0.86 | HEXA (0.69) | KDM4EALDH1A1POLBHPGDHK1 | |
| SCHEMBL20893694 | 0.86 | HEXA (0.69) | KDM4EALDH1A1POLBHPGDHK1 | |
| SCHEMBL14560557 | 0.86 | HEXA (0.69) | KDM4EALDH1A1POLBHPGDHK1 | |
| SCHEMBL1657181 | 0.86 | HEXA (0.69) | KDM4EALDH1A1POLBHPGDHK1 | |
| SCHEMBL9625427 | 0.86 | HEXA (0.69) | KDM4EALDH1A1POLBHPGDHK1 | |
| SCHEMBL9625491 | 0.86 | HEXA (0.69) | KDM4EALDH1A1POLBHPGDHK1 | |
| SCHEMBL11455625 | 0.86 | HEXA (0.69) | KDM4EALDH1A1POLBHPGDHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4927729-A | ELECTROGRAPHY | BAYER AKTIENGESELLSCHAFT (DE) | 1990-05-22 | — | — | US | disclosed |