SCHEMBL10429142

SCHEMBL10429142

CC(=O)Nc1ccc(C(=NO)C(C)=O)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.53
L3MBTL1 Q9Y468 3/20 0.53
HTT P42858 1/20 0.53
ALDH1A1 P00352 5/20 0.53
KMT2A Q03164 5/20 0.52
MAPT P10636 5/20 0.52
MEN1 O00255 3/20 0.52
CA1 P00915 2/20 0.52
CA2 P00918 2/20 0.52
TDP1 Q9NUW8 1/20 0.52
CA12 O43570 1/20 0.52
BRD4 O60885 1/20 0.52
NR1I2 O75469 1/20 0.52
MB P02144 1/20 0.52
CYP1A1 P04798 1/20 0.52
CA3 P07451 1/20 0.52
CYP3A4 P08684 1/20 0.52
RARG P13631 1/20 0.52
TSHR P16473 1/20 0.52
ALOX5AP P20292 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10740042 1.00 SMN1; SMN2 (0.53) SMN1; SMN2L3MBTL1HTTALDH1A1KMT2A
SCHEMBL10886486 0.78 HDAC1 (0.57) SMN1; SMN2L3MBTL1HTTALDH1A1KMT2A
SCHEMBL4320074 0.78 ALDH1A1 (0.56) SMN1; SMN2L3MBTL1HTTALDH1A1KMT2A
SCHEMBL8186057 0.78 HDAC1 (0.57) SMN1; SMN2L3MBTL1HTTALDH1A1KMT2A
SCHEMBL4320072 0.78 ALDH1A1 (0.56) SMN1; SMN2L3MBTL1HTTALDH1A1KMT2A
SCHEMBL10632992 0.78 SMN1; SMN2 (0.53) SMN1; SMN2L3MBTL1HTTALDH1A1KMT2A
SCHEMBL10632987 0.78 SMN1; SMN2 (0.53) SMN1; SMN2L3MBTL1HTTALDH1A1KMT2A
SCHEMBL861674 0.77 SMN1; SMN2 (0.84) SMN1; SMN2L3MBTL1HTTALDH1A1KMT2A
SCHEMBL11491554 0.76 ALDH1A1 (0.50) SMN1; SMN2HTTALDH1A1KMT2AMAPT
SCHEMBL11491555 0.76 ALDH1A1 (0.50) SMN1; SMN2HTTALDH1A1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4966855-A SUBSTITUTED OXAZOLES OR THIAZOLES, FOR DETECTING HYDROGEN PEROXIDE BOEHRINGER MANNHEIM GMBH (DE) 1990-10-30 US disclosed
EP-0167973-B1 REDOX INDICATORS Roche Diagnostics GmbH (DE) 1988-06-22 EP disclosed
EP-0161436-B1 REDOX INDICATORS Roche Diagnostics GmbH (DE) 1987-09-02 EP disclosed
US-4665023-A MEDICAL DIAGNOSIS BOEHRINGER MANNHEIM GMBH (DE) 1987-05-12 US disclosed
EP-0167973-A1 Redox indicators Roche Diagnostics GmbH (DE) 1986-01-15 EP disclosed
EP-0161436-A1 Redox indicators Roche Diagnostics GmbH (DE) 1985-11-21 EP disclosed