Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10429313 | 0.72 | NOTUM (0.38) | POLBTP53MAPTSMN1; SMN2PTGDR2 | |
| SCHEMBL10429372 | 0.72 | ROCK2 (0.52) | ROCK2POLBPDE3BPDE3ATP53 | |
| SCHEMBL11114283 | 0.70 | PDGFRB (0.55) | ROCK2POLBPDE3BPDE3ATP53 | |
| SCHEMBL10429350 | 0.70 | KDR (0.36) | PDE3BPDE3AALDH1A1 | |
| SCHEMBL9128045 | 0.69 | ROCK2 (0.69) | ROCK2POLBPDE3BPDE3ATP53 | |
| SCHEMBL11119482 | 0.69 | ROCK2 (0.62) | ROCK2POLBPDE3BPDE3ATP53 | |
| Benzyl Phenylcarbamate SCHEMBL1222943 | 0.69 | POLB (0.78) | ROCK2POLBTP53MAPTMGLL | |
| SCHEMBL10259763 | 0.69 | POLB (0.83) | ROCK2POLBPDE3BPDE3ATP53 | |
| SCHEMBL7297495 | 0.68 | ROCK2 (0.57) | ROCK2POLBPDE3BPDE3ATP53 | |
| SCHEMBL7295061 | 0.68 | ROCK2 (0.60) | ROCK2POLBPDE3BPDE3ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | claimed |
| US-4920119-A | XANTHINE OXIDASE INHIBITORS; CONTROL OR PREVENTION OF GOUT OR ISCHEMIA | HOFFMANN-LA ROCHE INC. (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0296374-A2 | Glycosylated aminoacids and peptides | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-12-28 | — | — | EP | disclosed |
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | disclosed |