Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10429687 | 1.00 | RIPK1 (0.36) | RIPK1CTSLCTSSCTSKHTR2A | |
| SCHEMBL9405858 | 0.96 | RIPK1 (0.38) | RIPK1CTSLCTSSCTSKHTR2A | |
| SCHEMBL9405855 | 0.96 | RIPK1 (0.38) | RIPK1CTSLCTSSCTSKHTR2A | |
| SCHEMBL9631308 | 0.95 | RIPK1 (0.36) | RIPK1HTR2AHTR2CHTR2BGRM2 | |
| SCHEMBL9631301 | 0.95 | RIPK1 (0.36) | RIPK1HTR2AHTR2CHTR2BGRM2 | |
| SCHEMBL10429847 | 0.95 | RIPK1 (0.36) | RIPK1HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL10429849 | 0.95 | RIPK1 (0.36) | RIPK1HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL10429738 | 0.95 | RIPK1 (0.36) | RIPK1HTR2AHTR2CHTR2BGRM2 | |
| SCHEMBL10429736 | 0.95 | RIPK1 (0.36) | RIPK1HTR2AHTR2CHTR2BGRM2 | |
| SCHEMBL9630303 | 0.94 | RIPK1 (0.35) | RIPK1HTR2AHTR2CHTR2BCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0400068-A1 | DERIVATIVES OF 2,3-DIFLUOROPHENOL | MERCK PATENT GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |
| WO-1989008632-A1 | DERIVATIVES OF 2,3-DIFLUOROPHENOL | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1989-09-21 | — | — | WO | disclosed |