Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | TOP2A | P11388 | 2/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2182815 | 0.81 | PDGFRB (0.60) | PDGFRAPDGFRBCYP1A2ALDH1A1MAPT | |
| SCHEMBL1045276 | 0.79 | PDGFRB (0.61) | PDGFRAPDGFRBPARP10PARP11MAP4K4 | |
| SCHEMBL462907 | 0.79 | PDGFRA (0.51) | PDGFRAPDGFRBPARP10PARP11MAP4K4 | |
| SCHEMBL1045337 | 0.77 | PDGFRB (0.56) | PDGFRAPDGFRBPARP10PARP11MAP4K4 | |
| SCHEMBL461745 | 0.74 | PDGFRB (0.51) | PDGFRAPDGFRBPARP10PARP11MAP4K4 | |
| SCHEMBL462976 | 0.74 | PDGFRB (0.51) | PDGFRAPDGFRBPARP10PARP11MAP4K4 | |
| SCHEMBL15968103 | 0.74 | CYP1A2 (0.56) | PDGFRAPDGFRBPARP10PARP11MAP4K4 | |
| SCHEMBL29375329 | 0.74 | CYP1A2 (0.56) | PDGFRAPDGFRBPARP10PARP11MAP4K4 | |
| SCHEMBL27833818 | 0.73 | PDGFRB (0.60) | PDGFRAPDGFRBBIRC5BRD4CREBBP | |
| SCHEMBL13658336 | 0.72 | PDGFRB (0.44) | PDGFRAPDGFRBPARP10PARP11MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011004132-A1 | NOVEL HSP90-INHIBITING INDOLE DERIVATIVES, COMPOSITIONS CONTAINING SAID DERIVATIVES, AND USE THEREOF | SANOFI-AVENTIS (FR) | 2011-01-13 | — | — | WO | disclosed |