Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 3/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.36 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | STK32B | Q9NY57 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2182815 | 0.74 | PDGFRB (0.60) | PDGFRBPDGFRABRD4CREBBPNISCH | |
| SCHEMBL1042969 | 0.72 | PDGFRA (0.51) | PDGFRBPDGFRAPARP10PARP11BRD4 | |
| SCHEMBL1045337 | 0.69 | PDGFRB (0.56) | PDGFRBPDGFRAPARP10PARP11BRD4 | |
| SCHEMBL1045276 | 0.68 | PDGFRB (0.61) | PDGFRBPDGFRAPARP10PARP11BRD4 | |
| SCHEMBL462976 | 0.68 | PDGFRB (0.51) | PDGFRBPDGFRAPARP10PARP11BRD4 | |
| SCHEMBL462907 | 0.68 | PDGFRA (0.51) | PDGFRBPDGFRAPARP10PARP11BRD4 | |
| SCHEMBL461745 | 0.68 | PDGFRB (0.51) | PDGFRBPDGFRAPARP10PARP11BRD4 | |
| SCHEMBL808411 | 0.68 | RAB9A (0.35) | CDK1MAPK1CYP2A6 | |
| SCHEMBL27833818 | 0.67 | PDGFRB (0.60) | PDGFRBPDGFRABRD4CREBBPNISCH | |
| SCHEMBL24203201 | 0.67 | KDM4E (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009122034-A2 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-10-08 | — | — | WO | disclosed |