Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 8/20 | 0.33 |
| ▸ | CNR1 | P21554 | 4/20 | 0.33 |
| ▸ | PNLIP | P16233 | 2/20 | 0.32 |
| ▸ | DAGLB | Q8NCG7 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.32 |
| ▸ | LPL | P06858 | 1/20 | 0.32 |
| ▸ | LIPC | P11150 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.32 |
| ▸ | ABHD12 | Q8N2K0 | 1/20 | 0.32 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367937 | 0.81 | DAGLA (0.39) | DAGLACNR1PNLIPDAGLBMAPT | |
| SCHEMBL10370562 | 0.81 | DAGLA (0.35) | DAGLACNR1PNLIPDAGLBMAPT | |
| SCHEMBL10367943 | 0.81 | DAGLA (0.35) | DAGLACNR1PNLIPDAGLBMAPT | |
| SCHEMBL10367939 | 0.80 | DAGLA (0.42) | DAGLACNR1PNLIPDAGLBMAPT | |
| SCHEMBL10368848 | 0.78 | DAGLA (0.36) | DAGLACNR1PNLIPDAGLBMAPT | |
| SCHEMBL10369297 | 0.76 | DAGLA (0.33) | DAGLACNR1 | |
| SCHEMBL9659447 | 0.75 | DAGLA (0.35) | DAGLACNR1PNLIPDAGLBMAPT | |
| SCHEMBL9825431 | 0.73 | DAGLA (0.38) | DAGLACNR1PNLIPDAGLBMAPT | |
| SCHEMBL10370899 | 0.72 | DAGLA (0.35) | DAGLACNR1PNLIPDAGLBMAPT | |
| SCHEMBL10370898 | 0.72 | DAGLA (0.35) | DAGLACNR1PNLIPDAGLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0349047-A2 | Treatment of diabetic ketoacidosis | MERCK & CO. INC. (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4873260-A | B-LACTONE ALKYLENE CARBOXYLIC ACIDS AND DERIVATIVES | MERCK & CO., INC. (US) | 1989-10-10 | — | — | US | disclosed |
| US-4806564-A | Antihypercholesterolemic beta-lactones | MERCK & CO., INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0293132-A1 | Antihypercholesterolemic beta-lactones | MERCK & CO. INC. (US) | 1988-11-30 | — | — | EP | disclosed |