Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 5/20 | 0.38 |
| ▸ | PRKCA | P17252 | 3/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | PNLIP | P16233 | 2/20 | 0.34 |
| ▸ | DAGLB | Q8NCG7 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.33 |
| ▸ | LPL | P06858 | 1/20 | 0.33 |
| ▸ | LIPC | P11150 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367940 | 0.81 | PRKCA (0.41) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL10373019 | 0.79 | PRKCA (0.35) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| Antibiotic 1233A SCHEMBL285679 | 0.75 | PRKCA (0.35) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| Antibiotic 1233A SCHEMBL613745 | 0.75 | PRKCA (0.35) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL716047 | 0.74 | PRKCA (0.43) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL716045 | 0.74 | PRKCA (0.43) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL9824730 | 0.74 | PRKCA (0.34) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL9576485 | 0.73 | DAGLA (0.35) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL10430879 | 0.73 | DAGLA (0.33) | DAGLAPNLIPDAGLBCNR1MAPT | |
| SCHEMBL14360676 | 0.70 | FFAR4 (0.44) | MEN1KMT2AHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0285254-B1 | ANTIHYPERCHOLESTEROLEMIC BETALACTONES | MERCK & CO. INC. (US) | 1991-07-10 | — | — | EP | disclosed |
| EP-0349047-A2 | Treatment of diabetic ketoacidosis | MERCK & CO. INC. (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4873260-A | B-LACTONE ALKYLENE CARBOXYLIC ACIDS AND DERIVATIVES | MERCK & CO., INC. (US) | 1989-10-10 | — | — | US | disclosed |
| US-4847271-A | Antihypercholesterolemic β-lactones | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0285254-A1 | Antihypercholesterolemic betalactones | MERCK & CO. INC. (US) | 1988-10-05 | — | — | EP | disclosed |
| US-4751237-A | ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1988-06-14 | — | — | US | disclosed |