Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HBB | P68871 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HPRT1 | P00492 | 10/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | PNP | P00491 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828688 | 0.89 | MEN1 (0.49) | MEN1KMT2AHBBMAPK1HPRT1 | |
| SCHEMBL29325413 | 0.79 | BLM (0.59) | MEN1KMT2AHBBHPRT1BLM | |
| SCHEMBL5653744 | 0.79 | BLM (0.59) | MEN1KMT2AHBBHPRT1BLM | |
| SCHEMBL8630516 | 0.77 | MEN1 (0.59) | MEN1KMT2AHBBHPRT1BLM | |
| SCHEMBL9827056 | 0.77 | BLM (0.53) | MEN1KMT2AHBBMAPK1HPRT1 | |
| SCHEMBL25611139 | 0.77 | PNP (0.53) | MEN1KMT2AHBBHPRT1BLM | |
| SCHEMBL7814355 | 0.76 | MEN1 (0.76) | MEN1KMT2AHBBMAPK1HPRT1 | |
| SCHEMBL5168886 | 0.75 | MEN1 (0.57) | MEN1KMT2AHBBHPRT1BLM | |
| SCHEMBL5555699 | 0.75 | HPRT1 (0.51) | MEN1KMT2AHBBMAPK1HPRT1 | |
| SCHEMBL8540040 | 0.74 | BLM (0.58) | MEN1KMT2AHBBMAPK1HPRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0400686-A1 | 2-Amino-9-[1,3bis-(isopropoxy)-propyl-2-oxymethyl]-purine, its utilization and medicaments containing it | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-12-05 | — | — | EP | disclosed |
| EP-0217207-A1 | 2-Amino purines substituted in positions 6 and 9, their use, medicaments containing these purines and processes for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-04-08 | — | — | EP | disclosed |