Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | CPT1A | P50416 | 5/20 | 0.52 |
| ▸ | CPT2 | P23786 | 4/20 | 0.52 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6527795 | 0.89 | CPT1A (0.50) | MEN1KMT2AMAPTCPT1ACPT2 | |
| SCHEMBL1045532 | 0.84 | CPT1A (0.47) | MEN1KMT2AMAPTCPT1ACPT2 | |
| SCHEMBL6523509 | 0.84 | CPT1A (0.50) | MAPTCPT1ACPT2CPT1BLMNA | |
| SCHEMBL1044681 | 0.84 | ALDH1A1 (0.49) | MEN1KMT2AMAPTCPT1ACPT2 | |
| SCHEMBL1044683 | 0.84 | CPT1A (0.46) | MEN1KMT2AMAPTCPT1ACPT2 | |
| SCHEMBL6521137 | 0.82 | MAPT (0.45) | MEN1KMT2AMAPTCPT1ACPT2 | |
| SCHEMBL28020746 | 0.81 | CPT1A (0.44) | MEN1KMT2AMAPTCPT1ACPT2 | |
| SCHEMBL13422230 | 0.81 | PTGER2 (0.42) | MAPTCPT1ACPT2CPT1BLMNA | |
| SCHEMBL13162592 | 0.80 | EPHX2 (0.39) | MAPTLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL13421200 | 0.79 | CPT1A (0.46) | MEN1KMT2AMAPTCPT1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271405-A2 | NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDORXYSTEROID DEHYDROGENASE-1 | Merck Patent GmbH (DE) | 2011-01-12 | — | — | EP | claimed |
| WO-2009135581-A9 | NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK PATENT GMBH (DE) | 2010-11-11 | — | — | WO | claimed |
| WO-2009135581-A2 | NOVEL NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK PATENT GMBH (DE) | 2009-11-12 | — | — | WO | claimed |
| EP-2271405-A2 | NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDORXYSTEROID DEHYDROGENASE-1 | Merck Patent GmbH (DE) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009135581-A9 | NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK PATENT GMBH (DE) | 2010-11-11 | — | — | WO | disclosed |
| WO-2009135581-A2 | NOVEL NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK PATENT GMBH (DE) | 2009-11-12 | — | — | WO | disclosed |