Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28465717 | 1.00 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL6291064 | 1.00 | — | — | |
| Piperazine SCHEMBL27338303 | 1.00 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL10439207 | 1.00 | HIF1A (0.75) | — | |
| Hydrochloric Acid SCHEMBL28472109 | 1.00 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL27437310 | 1.00 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL27689352 | 1.00 | — | — | |
| Piperazine SCHEMBL27400143 | 1.00 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL28525307 | 1.00 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL20258219 | 0.94 | HIF1A (0.86) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1080721-C | 1- (5-isoquinolinesulfonyl) homopiperazine hydrochloride hydrate | ASAHI CHEMICAL IND (JP) | 2002-03-13 | — | — | CN | claimed |
| CN-1183782-A | 1- (5-isoquinolinesulfonyl) homopiperazine hydrochloride hydrate | ASAHI CHEMICAL IND (JP) | 1998-06-03 | — | — | CN | claimed |
| CN-110198677-A | Embedded balloon with translating embedded filaments | 巴德股份有限公司 | 2019-09-03 | — | — | CN | disclosed |
| CN-104099026-B | Stable compressible silicon wafer polishing compositions and correlation technique | 罗门哈斯电子材料CMP控股股份有限公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-104099026-A | Stable, concentratable silicon wafer polishing composition and related methods | ROHM & HAAS ELECT MAT | 2014-10-15 | — | — | CN | disclosed |
| CN-104099027-A | Silicon wafer polishing composition and related methods | ROHM & HAAS ELECT MAT | 2014-10-15 | — | — | CN | disclosed |
| US-8801959-B1 | Stable, concentratable silicon wafer polishing composition and related methods | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. (US) | 2014-08-12 | — | — | US | disclosed |
| US-8795548-B1 | Silicon wafer polishing composition and related methods | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. (US) | 2014-08-05 | — | — | US | disclosed |
| CN-101139345-B | Polymorphic forms of 1-'4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride | MERCK PATENT GMBH | 2012-07-11 | — | — | CN | disclosed |
| CN-100384841-C | Polymorphic forms of 1- [4- (5-cyanoindol-3-yl) butyl ] -4- (2-carbamoyl-benzofuran-5-yl) -piperazine hydrochloride | MERCK PATENT GMBH (DE) | 2008-04-30 | — | — | CN | disclosed |
| CN-101139345-A | Polymorphic forms of 1-'4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride | MERCK PATENT GMBH (DE) | 2008-03-12 | — | — | CN | disclosed |
| CN-1516699-A | Polymorphic forms of 1- [ 4- (5-cyanoindol-3-yl) butyl ] -4- (2-carbamoyl-benzofuran-5-yl) -piperazine hydrochloride | Ĭ��ר���ɷ�����˾ | 2004-07-28 | — | — | CN | disclosed |
| CN-1080721-C | 1- (5-isoquinolinesulfonyl) homopiperazine hydrochloride hydrate | ASAHI CHEMICAL IND (JP) | 2002-03-13 | — | — | CN | disclosed |
| CN-1183782-A | 1- (5-isoquinolinesulfonyl) homopiperazine hydrochloride hydrate | ASAHI CHEMICAL IND (JP) | 1998-06-03 | — | — | CN | disclosed |
| CN-1085556-A | The 4-pyrimidyl and the pyridinyl derivatives of the indol-3-yl alkylpiperazine of anti-migraine | BRISTOL MYERS SQUIBB CO (US) | 1994-04-20 | — | — | CN | disclosed |
| EP-0361271-A1 | Pyridyl- and pyrimidyl derivatives | Kabi Pharmacia AB (SE) | 1990-04-04 | — | — | EP | disclosed |