Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL10439205 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL28465717 | 1.00 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL6291064 | 1.00 | — | — | |
| Piperazine SCHEMBL27338303 | 1.00 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL10439207 | 1.00 | HIF1A (0.75) | — | |
| Hydrochloric Acid SCHEMBL28472109 | 1.00 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL27437310 | 1.00 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL27400143 | 1.00 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL28525307 | 1.00 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL20258219 | 0.94 | HIF1A (0.86) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101068806-A | (S) - (-) -1- (4-fluoroisoquinolin-5-yl) sulfonyl-2-methyl-1, 4-homopiperazine hydrochloride dihydrate | KOWA CO (JP) | 2007-11-07 | — | — | CN | claimed |
| CN-1563001-A | Method for preparing terazosin hydrochloride of optical activity | DAOXIN MEDICINES INST CO LTD H (CN) | 2005-01-12 | — | — | CN | claimed |
| CN-101068806-A | (S) - (-) -1- (4-fluoroisoquinolin-5-yl) sulfonyl-2-methyl-1, 4-homopiperazine hydrochloride dihydrate | KOWA CO (JP) | 2007-11-07 | — | — | CN | disclosed |
| CN-1563001-A | Method for preparing terazosin hydrochloride of optical activity | DAOXIN MEDICINES INST CO LTD H (CN) | 2005-01-12 | — | — | CN | disclosed |