Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.63 |
| ▸ | RXRB | P28702 | 1/20 | 0.63 |
| ▸ | RXRG | P48443 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MAOA | P21397 | 4/20 | 0.58 |
| ▸ | MAOB | P27338 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10600292 | 0.86 | MAOB (0.69) | RXRARXRBRXRGMAOAMAOB | |
| SCHEMBL11381295 | 0.86 | ALDH1A1 (0.60) | RXRARXRBRXRGMAOAMAOB | |
| SCHEMBL10600206 | 0.85 | MAOB (0.70) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL18614358 | 0.84 | MEN1 (0.61) | MEN1KMT2AMAOAMAOBALDH1A1 | |
| SCHEMBL13462941 | 0.84 | MEN1 (0.61) | MEN1KMT2AMAOBMAPTALDH1A1 | |
| SCHEMBL4639017 | 0.84 | MEN1 (0.61) | MEN1KMT2AMAOAMAOBALDH1A1 | |
| SCHEMBL10597979 | 0.83 | KMT2A (0.66) | MEN1KMT2AMAOAMAOBMAPT | |
| SCHEMBL13439840 | 0.82 | MEN1 (0.58) | MEN1KMT2AMAOBMAPTNPC1 | |
| SCHEMBL4639013 | 0.82 | MEN1 (0.63) | MEN1KMT2AMAOAMAOBNPC1 | |
| SCHEMBL2962767 | 0.82 | KMT2A (0.52) | MEN1KMT2AMAOAMAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371564-A2 | (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-06 | — | — | EP | disclosed |