Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29405768 | 1.00 | KDM4E (0.36) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL23704316 | 0.80 | NAPRT (0.38) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL711130 | 0.78 | PTGDR2 (0.40) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28898087 | 0.77 | GRM5 (0.50) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL510673 | 0.77 | NOS3 (0.45) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL5802468 | 0.77 | TRIM24 (0.37) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL27896450 | 0.77 | KDM4E (0.34) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL16011703 | 0.74 | PLCG1 (0.38) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL26426502 | 0.74 | GRM5 (0.52) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL27896452 | 0.74 | CYP1A2 (0.35) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114106032-A | Preparation method of thiophene monomer and application of thiophene monomer in preparation of polythiophene anticorrosive paint | 江西省科学院应用化学研究所 | 2022-03-01 | — | — | CN | claimed |
| CN-114106032-B | Preparation method of thiophene monomer and application of thiophene monomer in preparation of polythiophene anti-corrosion coating | 江西省科学院应用化学研究所 | 2023-10-03 | — | — | CN | disclosed |
| WO-2022148459-A1 | CLASS OF NOVEL SMAD3 PROTEIN DEGRADERS AND APPLICATION THEREOF | 和径医药科技（上海）有限公司 | 2022-07-14 | — | — | WO | disclosed |
| CN-114106032-A | Preparation method of thiophene monomer and application of thiophene monomer in preparation of polythiophene anticorrosive paint | 江西省科学院应用化学研究所 | 2022-03-01 | — | — | CN | disclosed |
| US-8835423-B2 | Azepine inhibitors of janus kinases | INCYTE CORPORATION (US) | 2014-09-16 | — | — | US | disclosed |
| US-8835423-B2 | Azepine inhibitors of janus kinases | INCYTE CORPORATION (US) | 2014-09-16 | — | — | US | disclosed |
| US-20140031344-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2014-01-30 | — | — | US | disclosed |
| US-20140031344-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2014-01-30 | — | — | US | disclosed |
| US-8563541-B2 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION (US) | 2013-10-22 | — | — | US | disclosed |
| US-8563541-B2 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION (US) | 2013-10-22 | — | — | US | disclosed |
| EP-2270014-A1 | Azepine inhibitors of janus kinases | Incyte Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |
| US-20090197869-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION, A DELAWARE CORPORATION | 2009-08-06 | — | — | US | disclosed |
| US-20090197869-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION, A DELAWARE CORPORATION | 2009-08-06 | — | — | US | disclosed |
| EP-1926735-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | Incyte Corporation (US) | 2008-06-04 | — | — | EP | disclosed |
| US-20070149506-A1 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION | 2007-06-28 | — | — | US | disclosed |
| US-20070149506-A1 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION | 2007-06-28 | — | — | US | disclosed |
| WO-2007038215-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |
| US-5869482-A | Dipyridio 2,3-b:3',2'-! azepines and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACUETICALS, INC. (US) | 1999-02-09 | — | — | US | disclosed |
| WO-1998020002-A1 | DIPYRIDO[2,3-B:3',2'-F]AZEPINES AND THEIR USE IN THE PREVENTION OR TREATMENT OF HIV INFECTION | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1998-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197869-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | KDM4E 201/4885MEN1 1281/4885ALDH1A1 3705/4885 |
| US-20070149506-A1 | Azepine inhibitors of Janus kinases | JAK1, JAK3, JAK2 | KDM4E 201/4885MEN1 1281/4885ALDH1A1 3705/4885 |
| US-20140031344-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | KDM4E 201/4885MEN1 1281/4885ALDH1A1 3705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.