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NOS3

Nitric oxide synthase 3 · P29474 · NOS3 on Sugi Atlas →

102,862 patent compounds predicted against NOS3, 45,418 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL194469 SCHEMBL194469 1.00 10/20
SCHEMBL188501 SCHEMBL188501 0.52 9/20
SCHEMBL160399 SCHEMBL160399 0.73 6/20
SCHEMBL126967 SCHEMBL126967 0.56 6/20
SCHEMBL56189 SCHEMBL56189 0.56 6/20
SCHEMBL80890 SCHEMBL80890 0.54 6/20
SCHEMBL43288 SCHEMBL43288 0.73 5/20
Arginine Arginine (SCHEMBL43261) 0.72 5/20
SCHEMBL105611 SCHEMBL105611 0.70 5/20
SCHEMBL156221 SCHEMBL156221 0.68 5/20
SCHEMBL165970 SCHEMBL165970 0.67 5/20
SCHEMBL165971 SCHEMBL165971 0.67 5/20
SCHEMBL196828 SCHEMBL196828 0.67 5/20
SCHEMBL84142 SCHEMBL84142 0.63 5/20
SCHEMBL84401 SCHEMBL84401 0.52 5/20
Arginine Arginine (SCHEMBL1790) 0.50 5/20
Arginine Arginine (SCHEMBL1791) 0.50 5/20
Arginine Arginine (SCHEMBL29456) 0.50 5/20
Arginine Arginine (SCHEMBL15889) 0.49 5/20
Arginine Arginine (SCHEMBL15890) 0.49 5/20

Clinical trials — most relevant to NOS3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Nebivolol Effect on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients PHASE4COMPLETED
Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial PHASE3COMPLETED
L-Arginine in Pre-Eclampsia PHASE3COMPLETED
Effect of Rosiglitazone on ADMA in Critical Illness PHASE3UNKNOWN
COMP-4 Supplementation and Brachial Artery FMD PHASE1/PHASE2COMPLETED
Minocyclin in Ulcerative Colitis as Added on Therapy PHASE2COMPLETED
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE PHASE2UNKNOWN
Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients PHASE2COMPLETED
STRETCH Study: Effect of Distensibility on Endothelial-Dependent Vasoreactivity in Patients With ISH PHASE2COMPLETED
Evaluation of Two Doses of Nitric Oxide (NO) Given Intermittently Via Inhalation to Subjects With Bronchiolitis PHASE2COMPLETED
The STRETCH Study: Distensibility on Endothelial-Dependent Vasoreactivity in Subjects With Systolic Hypertension PHASE2COMPLETED
Influence of Dietary Nitrate on Skin Inflammation PHASE1COMPLETED
Possible Effects of Propylthiouracil, Riociguat and Perphenazine on Circulation of Healthy Volunteers PHASE1COMPLETED
Effect of Simvastatin on CF Airway Inflammation PHASE1COMPLETED
Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation PHASE1WITHDRAWN
iNOS With Positron Emission Tomography (PET) in Cellular Inflammation. EARLY_PHASE1COMPLETED
Influence of Pelacarsen on Patients After Myocardial Infarction With High Lp(a) Values (PEMILA) nanWITHDRAWN
Fetal Alcohol Spectrum Disorder-Is This a Ciliopathy? nanCOMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD nanUNKNOWN
Detection and Use of Nasal Nitrous Oxide and the Electronic Nose nanCOMPLETED
Markers of Cardiovascular Risk in Patients With Premature Coronary Artery Disease and Treatment nanUNKNOWN
NO Donors and Inhibitors to Study Imbalance of Nitrogen Stress and Antioxidant Defense in COPD nanCOMPLETED
Systemic Nitrosative/Oxidative Stress in Patients with Acute Brain Injury nanUNKNOWN
The Acute Effect of a Walnut Intervention on Cognitive Performance, Brain Activation, and Serum Markers of Inflammation in Young Adults nanCOMPLETED
High-Intensity Parent Intervention Program in Improving Learning and School Functioning in Latino Children With Acute Leukemia or Lymphoblastic Lymphoma nanACTIVE_NOT_RECRUITING
Effects of Trehalose and Polyphenols in Vasculopathic Patients nanCOMPLETED
OrthoCor Advanced Trial for Knee Osteoarthritis nanCOMPLETED
Genetics and Pain Severity in Sickle Cell Disease nanCOMPLETED
Effects of Nitrate-rich Beetroot Juice in Pregnant Women With High Blood Pressure nanUNKNOWN
Nitrate Supplementation and Exercise Tolerance in Patients With Type 2 Diabetes nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a NOS3 binder may also engage these)

ProteinNameSimilarity
Q9TUX8 — 1.000 Q9TUX8 →
P70313 — 0.999 P70313 →
Q28969 — 0.999 Q28969 →
Q62600 — 0.998 Q62600 →
P97270 — 0.997 P97270 →
P29473 — 0.997 P29473 →
P79209 — 0.995 P79209 →
Q80UW3 — 0.992 Q80UW3 →
Q8K330 — 0.990 Q8K330 →
Q28314 — 0.990 Q28314 →
Q8TER5 — 0.987 Q8TER5 →
Q75NR7 — 0.987 Q75NR7 →
NR4A1 Nuclear receptor subfamily 4immunitygroup A member 1 0.986 landscape →
A1L3T7 — 0.986 A1L3T7 →
Q8BLY7 — 0.986 Q8BLY7 →
Q562E7 — 0.986 Q562E7 →
Q8BV79 — 0.986 Q8BV79 →
D3YWQ0 — 0.986 D3YWQ0 →
Q5VZI3 — 0.985 Q5VZI3 →
Q5XIX0 — 0.985 Q5XIX0 →
Q3UIZ8 — 0.985 Q3UIZ8 →
Q8N5Z5 — 0.985 Q8N5Z5 →
Q8BHW9 — 0.984 Q8BHW9 →
P79290 — 0.984 P79290 →
P11299 — 0.984 P11299 →
Q60700 — 0.984 Q60700 →
O75064 — 0.984 O75064 →
Q5DTT2 — 0.984 Q5DTT2 →
Q5XIS1 — 0.984 Q5XIS1 →
Q92091 — 0.984 Q92091 →