Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL204641 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP2C19NPC1RAB9APSEN1 | |
| SCHEMBL205712 | 0.74 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL4346054 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP2C19NPC1RAB9APSEN1 | |
| SCHEMBL24998863 | 0.73 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP2C19NPC1RAB9APSEN1 | |
| SCHEMBL4330117 | 0.72 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP2C19NPC1RAB9APSEN1 | |
| SCHEMBL10440670 | 0.71 | SMN1; SMN2 (0.43) | SMN1; SMN2CYP2C19NPC1RAB9APSEN1 | |
| SCHEMBL206634 | 0.71 | ALDH1A1 (0.46) | SMN1; SMN2CYP2C19NPC1RAB9APSEN1 | |
| SCHEMBL203861 | 0.70 | SMN1; SMN2 (0.43) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL3952154 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP2C19NPC1RAB9APSEN1 | |
| SCHEMBL30403136 | 0.69 | SMN1; SMN2 (0.47) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0356193-A2 | Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters | PFIZER INC. (US) | 1990-02-28 | — | — | EP | disclosed |