SCHEMBL10440741

SCHEMBL10440741

CC(Oc1ccccc1)C(Br)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.49
GAA P10253 2/20 0.49
CYP2C9 P11712 1/20 0.49
PKM P14618 1/20 0.49
CYP2C19 P33261 1/20 0.49
MTNR1A P48039 1/20 0.45
MTNR1B P49286 1/20 0.45
ALDH1A1 P00352 2/20 0.42
KMT2A Q03164 4/20 0.41
MEN1 O00255 2/20 0.41
LMNA P02545 1/20 0.41
TP53 P04637 1/20 0.41
HPGD P15428 1/20 0.41
PTGS1 P23219 1/20 0.41
PPARG P37231 4/20 0.40
PPARA Q07869 4/20 0.40
LDHA P00338 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1716119 0.80 GAA (0.52) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL7805109 0.78 GAA (0.50) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL21386784 0.77 KDM4E (0.40) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL9541523 0.77 MTNR1A (0.43) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL2895193 0.77 CYP1A2 (0.49) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL2895192 0.77 CYP1A2 (0.49) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL1453272 0.76 CA4 (0.48) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL9495034 0.76 POLB (0.44) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL127395 0.75 CYP1A2 (0.78) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL5319015 0.75 CYP1A2 (0.46) CYP1A2GAACYP2C9PKMCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0381913-A1 Benzohydroxamic-acid derivatives SANDOZ AG (CH) 1990-08-16 EP disclosed