Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL7956618 | 0.98 | NOTUM (0.58) | NOTUMKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL8981929 | 0.95 | NOTUM (0.54) | NOTUMKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL31488059 | 0.90 | NOTUM (0.57) | NOTUMKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL27553596 | 0.86 | TSHR (0.56) | NOTUMKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL1716131 | 0.85 | SMN1; SMN2 (0.56) | NOTUMKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL27745558 | 0.85 | SMN1; SMN2 (0.56) | NOTUMKMT2AMEN1SMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL1859868 | 0.84 | SMN1; SMN2 (0.54) | NOTUMKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL1859866 | 0.84 | SMN1; SMN2 (0.54) | NOTUMKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL28941360 | 0.83 | L3MBTL1 (0.64) | NOTUMKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL27483254 | 0.83 | NOTUM (0.51) | NOTUMKMT2AMEN1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0386839-A2 | Tetrahydroquinoline derivatives useful for neurodegenerative disorders | MERCK SHARP & DOHME LTD. (GB) | 1990-09-12 | — | — | EP | disclosed |