SCHEMBL10448317

SCHEMBL10448317

Nc1nc2c(ncn2OCCSCP(=O)(O)O)c(=O)[nH]1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 14/20 0.53
PNP P00491 8/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9674741 0.85 HPRT1 (0.48) HPRT1PNP
SCHEMBL9684292 0.83 HPRT1 (0.69) HPRT1PNP
SCHEMBL9683440 0.82 PNP (0.70) HPRT1PNP
SCHEMBL9417159 0.82 HPRT1 (0.63) HPRT1PNP
SCHEMBL8781788 0.81 PNP (0.64) HPRT1PNP
SCHEMBL9857583 0.80 HPRT1 (0.61) HPRT1PNP
SCHEMBL10448323 0.79 HPRT1 (0.52) HPRT1PNP
SCHEMBL10448313 0.79 HPRT1 (0.52) HPRT1PNP
SCHEMBL9675832 0.79 HPRT1 (0.52) HPRT1PNP
SCHEMBL9576789 0.79 HPRT1 (0.64) HPRT1PNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0399743-A1 Phosphonomethylthio-alkoseypureine derivatives, intermediate products for their preparation and pharmaceutical compositions containing them BEECHAM GROUP PLC (GB) 1990-11-28 EP claimed
EP-0399743-A1 Phosphonomethylthio-alkoseypureine derivatives, intermediate products for their preparation and pharmaceutical compositions containing them BEECHAM GROUP PLC (GB) 1990-11-28 EP disclosed