Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 16/20 | 0.73 |
| ▸ | PRKACA | P17612 | 16/20 | 0.73 |
| ▸ | CDK2 | P24941 | 16/20 | 0.73 |
| ▸ | HIPK2 | Q9H2X6 | 16/20 | 0.73 |
| ▸ | PIM1 | P11309 | 15/20 | 0.73 |
| ▸ | GSK3B | P49841 | 15/20 | 0.73 |
| ▸ | CDK7 | P50613 | 10/20 | 0.73 |
| ▸ | CDK9 | P50750 | 10/20 | 0.73 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.73 |
| ▸ | STK17A | Q9UEE5 | 9/20 | 0.73 |
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.73 |
| ▸ | DAPK3 | O43293 | 8/20 | 0.73 |
| ▸ | CLK2 | P49760 | 8/20 | 0.73 |
| ▸ | PRKX | P51817 | 8/20 | 0.73 |
| ▸ | PKN2 | Q16513 | 8/20 | 0.73 |
| ▸ | MELK | Q14680 | 8/20 | 0.73 |
| ▸ | PRKD3 | O94806 | 7/20 | 0.73 |
| ▸ | PAK4 | O96013 | 7/20 | 0.73 |
| ▸ | FLT3 | P36888 | 7/20 | 0.73 |
| ▸ | JAK3 | P52333 | 7/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1044049 | 0.85 | ROCK2 (1.00) | ROCK2PRKACACDK2HIPK2PIM1 | |
| SCHEMBL1045953 | 0.84 | ROCK2 (0.86) | ROCK2PRKACACDK2HIPK2PIM1 | |
| SCHEMBL992341 | 0.83 | ROCK2 (0.84) | ROCK2PRKACACDK2HIPK2PIM1 | |
| SCHEMBL1043581 | 0.83 | CDK2 (0.73) | ROCK2PRKACACDK2HIPK2PIM1 | |
| SCHEMBL1044366 | 0.82 | CDC7 (0.80) | ROCK2PRKACACDK2HIPK2PIM1 | |
| SCHEMBL1044409 | 0.81 | ROCK2 (0.71) | ROCK2PRKACACDK2HIPK2PIM1 | |
| SCHEMBL1044445 | 0.81 | ROCK2 (0.76) | ROCK2PRKACACDK2HIPK2PIM1 | |
| SCHEMBL1042785 | 0.77 | CDC7 (1.00) | ROCK2PRKACACDK2HIPK2PIM1 | |
| SCHEMBL1041172 | 0.77 | CDC7 (1.00) | ROCK2PRKACACDK2HIPK2PIM1 | |
| SCHEMBL1046786 | 0.77 | ROCK2 (0.70) | ROCK2PRKACACDK2HIPK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454257-B1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBVIE INC (US) | 2013-08-21 | — | — | EP | claimed |
| US-8435980-B2 | Pyrrolopyridine inhibitors of kinases | ABBVIE INC. (US) | 2013-05-07 | — | — | US | claimed |
| EP-2454257-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | claimed |
| WO-2011008915-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | claimed |
| US-20110015173-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | US | claimed |
| EP-2454257-B1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBVIE INC (US) | 2013-08-21 | — | — | EP | disclosed |
| US-8435980-B2 | Pyrrolopyridine inhibitors of kinases | ABBVIE INC. (US) | 2013-05-07 | — | — | US | disclosed |
| EP-2454257-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008915-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | disclosed |
| US-20110015173-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015173-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | CDC7, MAP3K7, CDK1 | ROCK2 373/4885PRKACA 78/4885CDK2 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.