Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27945102 | 0.88 | KMT2A (0.49) | MAPK1PDE4APDE4BPDE4DLMNA | |
| SCHEMBL2847339 | 0.74 | MAPK1 (0.42) | MAPK1PDE4APDE4BPDE4DLMNA | |
| SCHEMBL25366278 | 0.73 | MAPK1 (0.41) | MAPK1PDE4APDE4BPDE4DLMNA | |
| SCHEMBL25366273 | 0.73 | MAPK1 (0.41) | MAPK1PDE4APDE4BPDE4DLMNA | |
| SCHEMBL11556653 | 0.72 | PDE4A (0.77) | MAPK1PDE4APDE4BPDE4DLMNA | |
| SCHEMBL27916057 | 0.70 | PDE4A (0.47) | MAPK1PDE4APDE4BPDE4DLMNA | |
| SCHEMBL410596 | 0.70 | MEN1 (0.47) | MAPK1PDE4APDE4BPDE4DLMNA | |
| SCHEMBL5496563 | 0.70 | MEN1 (0.47) | MAPK1PDE4APDE4BPDE4DLMNA | |
| SCHEMBL21678055 | 0.70 | CYP2D6 (0.49) | MAPK1LMNAMEN1KMT2ACYP2D6 | |
| SCHEMBL11321860 | 0.69 | CYP3A4 (0.65) | MAPK1PDE4APDE4BPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872101-B1 | Modulators of the orphan G protein-coupled receptors GPR78 and GPR26 | SCHERING CORPORATION (US) | 2011-01-18 | — | — | US | disclosed |
| US-20070270433-A1 | Thiazolo-pyrimidine/pyridine urea derivatives | BRINKMAN JOHN A | 2007-11-22 | — | — | US | disclosed |
| US-20050009847-A1 | Compounds and methods for increasing neurogenesis | NEURONOVA AB (COMPANY REGISTRATION NO. 556703-0118) (SE) | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270433-A1 | Thiazolo-pyrimidine/pyridine urea derivatives | ADORA2B, UTS2R, TBXA2R | MAPK1 1615/4885PDE4A 34/4885PDE4B 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.