Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 3/20 | 0.48 |
| ▸ | CES1 | P23141 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetophenone SCHEMBL2186216 | 0.93 | MAPT (0.58) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL9029344 | 0.88 | SMN1; SMN2 (0.58) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL11757006 | 0.86 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL30537005 | 0.85 | — | — | |
| Acetophenone SCHEMBL1450855 | 0.85 | — | — | |
| Acetophenone SCHEMBL30537000 | 0.85 | — | — | |
| Acetophenone SCHEMBL27462873 | 0.85 | MAPT (0.71) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL737 | 0.85 | — | — | |
| Acetophenone SCHEMBL16745259 | 0.85 | — | — | |
| Acetophenone SCHEMBL719033 | 0.85 | MAPT (0.71) | MAPTSMN1; SMN2HPGDALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221344-B1 | SULPHONYL-PHENYL ALKYL AMINES, PROCESS FOR THEIR PREPARATION AND MEDICINES | Roche Diagnostics GmbH (DE) | 1990-05-23 | — | — | EP | disclosed |
| EP-0221344-A1 | Sulphonyl-phenyl alkyl amines, process for their preparation and medicines | Roche Diagnostics GmbH (DE) | 1987-05-13 | — | — | EP | disclosed |
| EP-0031954-B1 | SULPHONAMIDES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1984-03-14 | — | — | EP | disclosed |
| EP-0031954-A2 | Sulphonamides, process for their preparation and medicines containing these compounds | Roche Diagnostics GmbH (DE) | 1981-07-15 | — | — | EP | disclosed |