Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332384 | 0.92 | SMN1; SMN2 (0.73) | SMN1; SMN2MAPK1MEN1KMT2ACYP2D6 | |
| SCHEMBL11568120 | 0.83 | SMN1; SMN2 (0.80) | SMN1; SMN2MAPK1MEN1KMT2ACYP2D6 | |
| SCHEMBL7775011 | 0.83 | NPC1 (0.62) | SMN1; SMN2MAPK1MEN1KMT2ACYP2D6 | |
| SCHEMBL10461568 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPK1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL7769079 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPK1MEN1KMT2ACYP2D6 | |
| SCHEMBL3062573 | 0.82 | SMN1; SMN2 (0.77) | SMN1; SMN2MAPK1MEN1KMT2ACYP2D6 | |
| SCHEMBL14176701 | 0.82 | SMN1; SMN2 (0.77) | SMN1; SMN2MAPK1MEN1KMT2ACYP2D6 | |
| SCHEMBL1545294 | 0.81 | L3MBTL1 (0.63) | SMN1; SMN2MAPK1CYP2D6ALDH1A1CYP1A2 | |
| SCHEMBL3079261 | 0.80 | SMN1; SMN2 (0.74) | SMN1; SMN2MAPK1MEN1KMT2ACYP2D6 | |
| SCHEMBL19612454 | 0.80 | SMN1; SMN2 (0.74) | SMN1; SMN2MAPK1MEN1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4950674-A | Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment | A. H. ROBINS COMPANY, INCORPORATED (US) | 1990-08-21 | — | — | US | disclosed |
| US-4810713-A | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0235463-A2 | N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1987-09-09 | — | — | EP | disclosed |