Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2258454 | 0.79 | CYP11B1 (0.49) | CYP11B1CYP11B2PRKCZADORA2AADORA1 | |
| SCHEMBL6175646 | 0.78 | CYP11B1 (0.45) | CYP11B1CYP11B2PRKCZADORA2AADORA1 | |
| Hydrochloric Acid SCHEMBL6845329 | 0.77 | CYP11B1 (0.47) | CYP11B1CYP11B2PRKCZADORA2AADORA1 | |
| SCHEMBL27594231 | 0.77 | CYP11B1 (0.42) | CYP11B1CYP11B2PRKCZADORA2AADORA1 | |
| SCHEMBL5353000 | 0.76 | CYP11B1 (0.44) | CYP11B1CYP11B2PRKCZADORA2AADORA1 | |
| SCHEMBL4820933 | 0.76 | CYP11B2 (0.44) | CYP11B1CYP11B2PRKCZADORA2AADORA1 | |
| SCHEMBL11150207 | 0.75 | CYP11B1 (0.43) | CYP11B1CYP11B2PRKCZADORA2AADORA1 | |
| SCHEMBL9572666 | 0.73 | CYP11B2 (0.47) | CYP11B1CYP11B2PRKCZADORA2AADORA1 | |
| SCHEMBL9520783 | 0.71 | CHAT (0.41) | PRKCZADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL10399111 | 0.71 | CHAT (0.41) | PRKCZADRA2AADRA2BADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4916145-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | HOFFMANN-LA ROCHE INC. (US) | 1990-04-10 | — | — | US | disclosed |